Table 3.
Brain regions exhibiting significant differences in RSFC with the abnormal FCD regions (in italic) between the SAD and HC groups
Regions | Side | BA | t | Size | MNI |
|||
---|---|---|---|---|---|---|---|---|
x | y | z | ||||||
Right rACC | ||||||||
SAD >HC | None | |||||||
SAD <HC | ||||||||
Cluster 1 | STG | R | 21 | 5.73 | 105 | 69 | −12 | −6 |
Cluster 2 | Precuneus/MCC | R/L | 7/31 | 5.59 | 426 | 0 | −30 | 48 |
Cluster 3 | SFGa | L | 9 | 4.82 | 35 | −18 | 45 | 36 |
Cluster 4 | MFGa | R | 6/8 | 4.47 | 58 | 30 | 15 | 60 |
Cluster 5 | SFGa | R | 10 | 4.21 | 45 | 15 | 63 | 18 |
Right STG | ||||||||
SAD >HC | None | |||||||
SAD <HC | ||||||||
Cluster 1 | STG | L | 43/41/22/42 | 5.34 | 344 | −54 | −12 | 9 |
Cluster 2 | Insula | R | 13/21/22 | 5.02 | 262 | 33 | 6 | 6 |
Putamen | R | |||||||
Cluster 3 | STGa | R | 42/43/21/21 | 4.97 | 385 | 66 | −18 | 9 |
Cluster 4 | PTCG/PRCG | R | 4/6/3 | 4.52 | 180 | 51 | −18 | 54 |
Cluster 5 | Middle TPO | R | 38 | 4.33 | 26 | 30 | 15 | −39 |
Cluster 6 | PRCG/PTCG | L | 4/6 | 4.30 | 97 | −42 | −15 | 54 |
Cluster 7 | SMA | L | 6/24 | 3.93 | 44 | −3 | −6 | 54 |
Cluster 8 | IFG | R | 46 | 3.88 | 57 | 30 | 27 |
Coordinates refer to the local peak within each cluster. Results were thresholded at FDR < 0.05, K > 20. rACC, rostral anterior cingulate cortex; STG, superior temporal gyrus; MCC, middle cingulate cortex; SFG, superior frontal gyrus; MFG, middle frontal gyrus; PTCG, postcentral gyrus; PRCG, precentral gyrus; TPO, temporal pole; SMA, supplementary area; IFG, inferior frontal gyrus. BA, Broadmann area; MNI, Montreal Neurological Institute; L, left hemisphere; R, right hemisphere; SAD, social anxiety disorder; HC, healthy control.
RSFC between these regions and the abnormal FCD regions contributed most substantially to SAD diagnosis