Skip to main content
. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: J Toxicol Environ Health A. 2017;80(1):53–68. doi: 10.1080/15287394.2016.1238329

Figure 5. IL-1α modulation of NGF expression.

Figure 5

TiO2–FP exposure increased IL-1α synthesis in bronchial epithelial cells and exogenous IL-1α increased NGF gene expression to levels similar to TiO2-NP, while pretreatment with a specific receptor antagonist (IL1α-ra) abolished the effect of TiO2-NP exposure on NGF gene expression (A). Similar results were obtained by analyzing the expression of proNGF protein by Western blot (B) or FACS (C). Data are expressed as means ± SDs of 3 independent experiments. *p<0.05 compared to control cells not exposed to TiO2.