Figure 8. Anti-apoptotic effect of anti-p75^NTR.

Selective immunologic blockade of the cell death receptor p75^NTR inhibited TiO₂-NP induced apoptosis. Lower respiratory tract bronchial (A) and alveolar (B) epithelial cells were pretreated anti-human p75^NTR antibody for 24 h before exposure to 10 μg/ml of TiO₂-NP. Control group was treated with human IgG antibody. Cells were harvested, stained with annexin V-FITC and propidium iodide (PI), and viability was analyzed by FACS. Data shown are the means ± SDs of 3 independent experiments. *p<0.05 compared to control cells.