TABLE 8 .

Lab C spiking study: analysis of DNA (cell pellet plus mixed-virus spike)

Reference virus genome	High spikea (312,550,440)d		Medium spikeb (394,850,748)		Low spikec (354,248,828)		No spike (220,064,594)
	No. of reads	% genome coverede	No. of reads	% genome coverede	No. of reads	% genome coverede	No. of reads	% genome coverede
EBV	1,195,993	100.0	23,931	99.6	730	33.6	0	0
RSV	0	0.0	2	1.3	0	0.0	0	0
FeLV	2	2.2	0	0.0	0	0.0	0	0
REO1	2	NDf	0	0.0	4	ND	0	0
HPV18	1,762	66.7	2,765	64.4	2,709	65.5	1,527	66.7

^aHigh spike, 100 copies per cell.

^bMedium spike, 3 copies per cell.

^cLow spike, 0.1 copy per cell.

^dThe total read number is shown in parentheses.

^ePercentage of viral genome covered by the mapped reads.

^fND, not determined because reads map to different segments.