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. 2017 Sep 13;37(37):9037–9053. doi: 10.1523/JNEUROSCI.0811-17.2017

Figure 4.

Figure 4.

Basal intracellular calcium levels in corticospinal neurons measured in vivo are significantly elevated in hSOD1G93A mice. A, Images of cross sections of the apical dendritic stalks of two CSNs in control (WT) and in hSOD1G93A mice showing the tdTomato signal (left), the GCaMP6s signal (middle), and the two overlaid (right). Scale bar, 2 μm. B, The cumulative plot of the mean intensity of the tdTomato fluorescence (hSOD1G93A: 33.9 ± 3.8 a.u., n = 40 neurons from 12 mice; WT: 38.6 ± 4.2 a.u., n = 52 neurons from 16 mice; p = 0.3884, Mann–Whitney test). C, The cumulative plot of the ratio of the GCaMP6s intensity to the tdTomato intensity (hSOD1G93A: 1.6 ± 0.2, n = 40 neurons from 12 mice; WT: 1.1 ± 0.2, n = 52 neurons from 16 mice; p = 0.0011, Mann–Whitney test).