Table 1.
Electrophysiological properties of cortical neurons recorded from symptomatic (P90–P129) hSOD1G93A or control mice
| p value (Mann–Whitney test) | |||
|---|---|---|---|
| CSN (P90–P129) | WT (46 cells, 12 mice) | hSOD1G93A (64 cells, 19 mice) | |
| Resting membrane potential (mV) | −74.39 ± 0.52 | −72.91 ± 0.57 | 0.0735 |
| Input resistance (MΩ) | 51.19 ± 1.9 | 56.7 ± 1.73 | 0.0147 |
| Spike threshold (mV) | −37.4 ± 0.66 | −36.03 ± 0.77 | 0.3271 |
| Spike amplitude (mV) | 68.04 ± 1.09 | 66.95 ± 1.24 | 0.9283 |
| Spike half-width (ms) | 0.53 ± 0.01 | 0.55 ± 0.01 | 0.1868 |
| CCN (P90–P129) | WT (36 cells, 11 mice) | hSOD1G93A (50 cells, 19 mice) | |
| Resting membrane potential (mV) | −81.57 ± 0.68 | −79.15 ± 0.86 | 0.0767 |
| Input resistance (MΩ) | 79.3 ± 2.64 | 109.13 ± 5.38 | <0.0001 |
| Spike threshold (mV) | −33.44 ± 0.7 | −34.94 ± 0.63 | 0.1868 |
| Spike amplitude (mV) | 67.14 ± 1.46 | 63.68 ± 1.15 | 0.0257 |
| Spike half-width (ms) | 0.64 ± 0.01 | 0.71 ± 0.01 | <0.0001 |
| PV (P90–P101) | WT (25 cells, 9 mice) | hSOD1G93A (21 cells, 8 mice) | |
| Resting membrane potential (mV) | −73.84 ± 0.97 | −73.35 ± 1.39 | 0.9648 |
| Input resistance (MΩ) | 135.68 ± 8.61 | 183.78 ± 22.80 | 0.0609 |
| Spike threshold (mV) | −36.86 ± 1.15 | −35.49 ± 1.03 | 0.7491 |
| Spike amplitude (mV) | 53.31 ± 1.75 | 47.51 ± 2.19 | 0.0497 |
| Spike half-width (ms) | 0.29 ± 0.02 | 0.33 ± 0.02 | 0.0039 |