Table 2.
Electrophysiological properties of cortical neurons recorded from presymptomatic (P26–P40) hSOD1G93A or control mice
| p-value (Mann-Whitney test) | |||
|---|---|---|---|
| CSN (P26–P40) | WT (33 cells, 11 mice) | hSOD1G93A (56 cells, 12 mice) | |
| Resting membrane potential (mV) | −71.5 ± 1.34 | −68.72 ± 0.84 | 0.0474 |
| Input resistance (MΩ) | 58.48 ± 2.63 | 60.72 ± 2.28 | 0.6866 |
| Spike threshold (mV) | −35.49 ± 1.76 | −34.92 ± 1.01 | 0.8418 |
| Spike amplitude (mV) | 76.88 ± 1.47 | 75.68 ± 1.08 | 0.9831 |
| Spike half-width (ms) | 0.66 ± 0.01 | 0.66 ± 0.02 | 0.8784 |
| CCN (P26–P40) | WT (25 cells, 7 mice) | hSOD1G93A (13 cells, 5 mice) | |
| Resting membrane potential (mV) | −73.53 ± 1.41 | −75.4 ± 2.09 | 0.3401 |
| Input resistance (MΩ) | 88.32 ± 4.9 | 97.92 ± 6.32 | 0.1962 |
| Spike threshold (mV) | −29.48 ± 2.08 | −27.15 ± 1.92 | 0.4237 |
| Spike amplitude (mV) | 66.56 ± 1.64 | 65.46 ± 2.42 | 0.8777 |
| Spike half-width (ms) | 0.76 ± 0.03 | 0.71 ± 0.03 | 0.2354 |
| PV (P26–P35) | WT (17 cells, 7 mice) | hSOD1G93A (18 cells, 6 mice) | |
| Resting membrane potential (mV) | −76.87 ± 2.22 | −72.58 ± 2.22 | 0.1248 |
| Input resistance (MΩ) | 127.11 ± 12.5 | 117.32 ± 10.44 | 0.6321 |
| Spike threshold (mV) | −40.47 ± 2.13 | −37.69 ± 2.57 | 0.6323 |
| Spike amplitude (mV) | 56.07 ± 2.66 | 51.88 ± 2.85 | 0.1924 |
| Spike half-width (ms) | 0.36 ± 0.03 | 0.3 ± 0.01 | 0.2204 |