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. 2017 Sep 13;18:728. doi: 10.1186/s12864-017-4117-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Top: PCA based on 1308 CpG sites significant (FDR < 0.05) in CLL cases and with minimal variation between WBC sub-populations. Bottom: similar analysis with 1308 CpG sites randomly selected from among those with FDR > 0.8 in CLL cases and with minimal variation between WBC sub-populations. The signal intensities employed were denoised for various parameters, including B-cell content (see Methods). The numbers in the Figures on the right indicate the fractional B-cell content of the samples. The Figures on the left show all subjects while those on the right show only the CLL case subjects