Fig. 5.

Analysis of in vitro intra-hepatic sporozoite development inhibition by CPS-induced antibodies, cellular responses and protection status in vivo. CPS-induced antibody-mediated inhibition of in vitro challenge strain intra-hepatic development and cytotoxic and cytokine-producing T cell responses to NF54-infected erythrocytes are shown. The 10th and 90th percentile of each response in all (n = 19) CPS-immunized volunteers that received a heterologous challenge infection are shown as grey box-and-whisker plots. The green triangle represents 1 out of 9 CPS-immunized volunteers sterilely protected against NF166.C8 challenge infection, while the orange square and upside down triangle represent the 2 out of 10 CPS-immunized volunteers with sterile protection against NF135.C10 challenge infection