Table 3.
α-Cypermethrin, malondialdehyde, α-tocopherol, glutathione and glutathione disulfide in liver, kidney and adipose tissues of rats fed control diets or identical diets supplemented with α-cypermethrin, curcumin, or a mixture of α-cypermethrin and curcumin for seven weeks.a
| Control | α-Cypermethrin | Curcumin | α-Cypermethrin + Curcumin | P | |
|---|---|---|---|---|---|
| α-Cypermethrin (ng/g) | |||||
| Liver | n.d. | 53.2 ± 92.9 | n.d. | 84.2 ± 161.4 | 0.605 |
| Kidney | n.d. | 523.9 ± 522.3 | n.d. | 701.5 ± 548.3 | 0.468 |
| Brain | n.d. | 17.5 ± 11.5 | n.d. | 10.3 ± 4.9 | 0.085 |
| Visceral adipose tissue | n.d. | 9813 ± 2093 | n.d. | 8955 ± 2051 | 0.367 |
| Subcutaneous adipose tissue | n.d. | 9288 ± 2325 | n.d. | 9252 ± 5329 | 0.985 |
| Malondialdehyde (μmol/g) | |||||
| Liver | 0.099 ± 0.066 | 0.105 ± 0.084 | 0.124 ± 0.105 | 0.217 ± 0.147 | 0.058 |
| Kidney | 0.047 ± 0.007 | 0.051 ± 0.008 | 0.045 ± 0.009 | 0.051 ± 0.008 | 0.235 |
| Brain | 0.005 ± 0.001 | 0.004 ± 0.005 | 0.005 ± 0.001 | 0.004 ± 0.001 | 0.125 |
| Visceral adipose tissue | 142.0 ± 48.9ab | 202.0 ± 53.6a | 131.1 ± 40.2b | 175.6 ± 76.0ab | 0.031 |
| Subcutaneous adipose tissue | 116.4 ± 39.2ab | 125.4 ± 53.0ab | 84.7 ± 43.4a | 144.8 ± 37.7b | 0.032 |
| α-Tocopherol (nmol/g) | |||||
| Liver | 5.19 ± 3.51 | 5.36 ± 3.48 | 8.35 ± 3.80 | 6.32 ± 3.30 | 0.186 |
| Kidney | 2.92 ± 0.35ab | 2.40 ± 0.44a | 3.27 ± 0.46b | 2.68 ± 0.58a | 0.001 |
| Brain | 1.84 ± 0.32a | 2.89 ± 0.74b | 2.23 ± 0.45ab | 2.21 ± 0.77ab | 0.005 |
| Visceral adipose tissue | 6.04 ± 0.96ab | 5.52 ± 0.85a | 7.30 ± 1.69b | 6.05 ± 1.09ab | 0.015 |
| Subcutaneous adipose tissue | 3.83 ± 1.10ab | 2.92 ± 0.62a | 4.23 ± 1.04b | 3.41 ± 0.42ab | 0.009 |
| Glutathione | |||||
| Liver (μmol/g) | 3.0 ± 0.5 | 2.9 ± 0.5 | 3.2 ± 0.4 | 3.4 ± 0.5 | 0.240 |
| Kidney (nmol/g) | 14.3 ± 4.4a | 20.8 ± 11.5ab | 19.4 ± 8.4ab | 25.6 ± 6.5b | 0.031 |
| Visceral adipose tissue (nmol/g) | 3.7 ± 1.5 | 4.8 ± 1.7 | 5.2 ± 2.4 | 5.1 ± 2.0 | 0.343 |
| Subcutaneous adipose tissue (nmol/g) | 6.4 ± 3.8 | 7.1 ± 2.9 | 4.8 ± 1.2 | 6.9 ± 4.0 | 0.419 |
| Glutathione disulfide | |||||
| Liver (μmol/g) | 0.14 ± 0.05ab | 0.23 ± 0.09a | 0.12 ± 0.05b | 0.20 ± 0.10ab | 0.008 |
| Kidney (nmol/g) | 2.9 ± 0.9a | 8.3 ± 2.4b | 2.9 ± 1.5a | 9.1 ± 2.4b | <0.001 |
| Visceral adipose tissue (nmol/g) | 32.1 ± 6.5ab | 37.1 ± 6.8a | 29.0 ± 3.9b | 36.7 ± 5.8a | 0.014 |
| Subcutaneous adipose tissue (nmol/g) | 23.6 ± 2.8a | 37.8 ± 8.4b | 26.4 ± 6.3ac | 35.2 ± 9.4bc | <0.001 |
a
Values within a row not sharing a common superscript letter are significantly different at P < 0.05.