Fig. 1.

Changes in cardiovascular biomarkers. The data are expressed as medians with interquartile ranges (IQR). The Mann–Whitney test was used for the comparison of the healthy control group (striated column) with the patients with chronic heart failure (blank columns). The changes in the cardiovascular biomarkers of the patients with heart failure after cardiac resynchronization therapy were assessed using the Friedman test with Dunn post-hoc analysis (C = control level, B = baseline level, 6 = 6-month level, and 2 = 2-year level). NT-proBNP = N-terminal of the prohormone brain natriuretic peptide; CK = creatine kinase; CKMB = creatine kinase MB isoenzyme; LDH = lactate dehydrogenase. N (control) = 122; n (baseline) = 129; n (6-month) = 105; n (2-year) = 83. *0.01 ≤ p < 0.05; **0.001 ≤ p < 0.01; ***p < 0.001; ns = not significant