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. 2014 Jul 2;1:411–420. doi: 10.1016/j.toxrep.2014.06.009

Fig. 4.

Fig. 4

Effects of E. ivorense leaf and stem bark and P. nigrescens extracts on kidney tissue of treated and untreated Wistar rats. (G1) EIML 100 mg/kg: improved vasculature and a good number of glomerular tufts with no notable changes. (G2) EIML 300 mg/kg: highly vascularized kidney with a good number of glomerular tufts. (G3) EIML 1000 mg/kg: Persistent renal tissue inflammation and glomerular degeneration, evident of reduced immunity. (G4) EIMB 100 mg/kg: diseased kidney with profuse renal tissue inflammation, glomerular necrosis and vacuolation, evident of kidney degeneration. (G5) EIMB 300 mg/kg: profuse glomerular degeneration with persistent renal tissue inflammation, indicative of persistent poor treatment response. (G6) EIMB 1000 mg/kg: persistent renal toxicity with profuse haemorrhage, glomerular degeneration, reflective of treatment failure. (G7) PNML 100 mg/kg: persistent hyalination and haemorrhage with focal inflammatory cells infiltration indicative of persistent kidney damage due to reduced immunity. (G8) PNML 300 mg/kg: profuse haemorrhage and persistent renal tissue inflammation reflective of poor immune response. (G9) PNML 1000 mg/kg: a good number of restoring glomerular tufts with improved vasculature suggestive of recovery. (G10) Control 000 mg/kg: Normal kidney highly vascularized with a good number of glomerular tufts. Legend: RnT: renal tissue; RV: reduced vacuolation; TV: tissue vasculature; AS: apoptotic space; DG: degenerating glomeruli; G: glomeruli; GT: glomerular tubules; H: haemorrhage; HT: hyalinized tissue; IC: infiltrating cells; IT: inflamed tissue; NG: necrotic glomerulus; OT: occluding tubules.