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. 2014 Jul 2;1:411–420. doi: 10.1016/j.toxrep.2014.06.009

Fig. 5.

Fig. 5

Effects of E. ivorense leaf and stem bark and P. nigrescens extracts on liver tissue of both treated and untreated Wistar rats. (G1) EIML 100 mg/kg: healthy hepatocytes and sinusoids, indicative of effective treatment response. (G2) EIML 300 mg/kg: marginal inflammatory infiltrates with healthy hepatocytes and sinusoids, indicative of recovery. (G3) EIML 1000 mg/kg: increased inflammatory infiltrates with few vacuolations and scarrings, indicative of persistent disease. (G4) EIMB 100 mg/kg: diseased liver with profuse inflammatory cell infiltration and hepatocyte necrosis. (G5) EIMB 300 mg/kg: inflamed liver with hepatocyte necrosis, suggestive of sustained hepatotoxicity. (G6) EIMB 1000 mg/kg: sustained inflammation with satellite hepatocyte necrosis, suggestive of impending hepatotoxicity. (G7) PNML 100 mg/kg: increased inflammatory infiltrates with scarring and central venous congestion suggestive of poor immunity. (G8) PNML 300 mg/kg: persistent inflammation with few scarrings and occluding vasculature, evident of sustained disease. (G9) PNML 1000 mg/kg: reduced inflammatory infiltrates with healthy hepatocytes and tissue proliferation, indicative of liver restitution. (G10) Control 000 mg/kg: normal liver with healthy hepatocytes and sinusoids. Legend: AS: apoptotic space; CV: congested vein; HN: hepatocyte necrosis; HP: hepatocytes; IC: inflammatory cells; IH: inflamed hepatocytes; RT: regenerating tissue; S: sinusoids; SN: satellite necrosis; ST: scar tissue; V: vacuolation.