Table 2.

Effects of methanol extracts on haematological parameters of Wistar rats in subchronic toxicity studies.

Parameters	Extracts and their concentration (mg/kg body weight)
	EIML 100	EIML 300	EIML 1000	EIMB 100	EIMB 300	EIMB 1000	PNML 100	PNML 300	PNML 1000	CONTROL
WBC X 103/μL	11.0 ± 0.50	11.2 ± 0.60	7.18 ± 0.75	16.2 ± 0.12	13.2 ± 1.00	12.1 ± 0.74	8.20 ± 0.47*	8.16 ± 1.11*	11.0 ± 0.25	12.0 ± 0.58
RBC X 106/μL	8.81 ± 0.19*	8.43 ± 0.08*	8.24 ± 0.12*	8.58 ± 0.18*	8.31 ± 0.08*	7.74 ± 0.05	7.98 ± 0.12	8.27 ± 0.19*	8.42 ± 0.14*	7.25 ± 0.33
HGB (g/dL)	15.6 ± 0.27*	15.1 ± 0.21*	15.0 ± 0.24*	15.5 ± 0.20*	14.9 ± 0.12*	14.2 ± 0.09*	14.5 ± 0.27*	14.9 ± 0.28*	15.4 ± 0.31*	13.2 ± 0.26
HCT (%)	56.3 ± 1.25*	54.0 ± 0.54*	54.4 ± 1.17*	54.6 ± 0.83*	52.6 ± 0.46*	50.8 ± 1.25*	50.0 ± 1.25*	51.2 ± 1.33*	54.2 ± 1.35*	43.9 ± 2.15
MCV (fL)	63.9 ± 0.75	64.1 ± 0.55	66.0 ± 0.87*	63.7 ± 0.70	63.3 ± 0.71	65.6 ± 1.64*	62.7 ± 0.41	61.9 ± 0.52	64.3 ± 0.64	60.8 ± 1.27
MCHC (g/dL)	27.8 ± 0.21*	28.0 ± 0.37*	27.6 ± 0.37*	28.4 ± 0.50	28.3 ± 0.16	28.1 ± 0.79	28.9 ± 0.69	29.2 ± 0.31	28.4 ± 0.21	30.0 ± 0.43
PLT X 103/μL	702 ± 56.10	730 ± 35.4	688 ± 31.8	839 ± 117	767 ± 36.7	647 ± 23.1	748 ± 32.4	665 ± 23.4	751 ± 19.2	596 ± 42.7
LYM (%)	78.4 ± 4.74	73.8 ± 1.85	69.3 ± 1.52	72.6 ± 2.60	69.5 ± 1.96	72.8 ± 7.69	72.8 ± 11.1	77.4 ± 1.78	74.6 ± 1.46	78.9 ± 1.12
NEUT (%)	21.6 ± 4.74	26.2 ± 1.85	30.7 ± 1.52*	27.4 ± 2.60*	30.5 ± 1.96*	27.2 ± 7.69	27.3 ± 11.1*	22.6 ± 1.78	25.4 ± 1.46*	21.1 ± 1.12
LYM # X 103/μL	8.54 ± 0.48	8.26 ± 0.59	4.98 ± 0.53*	10.2 ± 1.16	9.20 ± 0.94	8.40 ± 1.82	7.73 ± 1.06	6.32 ± 0.87	8.18 ± 0.35	9.47 ± 0.90
NEUT#X 103/μL	2.42 ± 0.58	2.90 ± 0.11	2.20 ± 0.26	3.97 ± 0.85	3.98 ± 0.17	2.80 ± 0.40	4.70 ± 3.20	1.84 ± 0.27	2.78 ± 0.14	2.53 ± 0.19

WBC – white blood cells; RBC – red blood cells; HGB – haemoglobin; HCT – haematocrit; MCV – mean corpuscular volume; MCHC – mean corpuscular haemoglobin concentration; PLT – platelets; LYM – lymphocytes; NEUT – neutrophils.

^*p < 0.05 (statistically significant).