Table 3.
Effects of methanol extracts on general biochemical parameters of treated and untreated Wistar rats.
| Parameters | Extracts and their concentration (mg/kg body weight) |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| EIML 100 | EIML 300 | EIML 1000 | EIMB 100 | EIMB 300 | EIMB 1000 | PNML 100 | PNML 300 | PNML 1000 | CONTROL | |
| Tot protein (g/L) | 92.8 ± 2.11 | 92.7 ± 1.44 | 85.1 ± 1.22 | 89.5 ± 3.31 | 82.5 ± 1.50 | 84.6 ± 3.76 | 85.7 ± 5.20 | 83.0 ± 2.50 | 85.0 ± 1.66 | 85.2 ± 3.36 |
| ALT/GPT (U/L) | 6.94 ± 1.46* | 32.6 ± 10.6* | 48.5 ± 17.2* | 34.7 ± 14.6* | 21.8 ± 6.33* | 30.5 ± 22.9* | 64.0 ± 20.3* | 47.1 ± 11.4* | 36.9 ± 9.42* | 112 ± 4.02 |
| AST/GOT (U/L) | 3.46 ± 0.61 | 3.52 ± 0.78 | 4.28 ± 1.28 | 4.13 ± 0.85 | 5.52 ± 0.53 | 4.23 ± 1.24 | 5.33 ± 0.74 | 4.26 ± 0.74 | 4.30 ± 0.86 | 4.30 ± 0.46 |
| Total bilirubin | 2.78 ± 0.11* | 2.69 ± 0.12* | 2.87 ± 0.15* | 2.66 ± 0.29* | 2.87 ± 0.20* | 2.63 ± 0.12* | 2.41 ± 0.09 | 2.36 ± 0.04 | 2.31 ± 0.11 | 1.94 ± 0.09 |
| Gamma-GT (U/L) | 4.62 ± 1.22 | 4.20 ± 0.72 | 9.22 ± 2.23 | 8.60 ± 3.86 | 7.06 ± 3.83 | 5.03 ± 1.44 | 11.1 ± 7.90 | 1.86 ± 0.56 | 4.30 ± 1.64 | 6.37 ± 2.88 |
| Creatinine (μmol/L) | 81.0 ± 4.58 | 72.5 ± 3.94 | 75.5 ± 5.46 | 73.9 ± 5.15 | 76.2 ± 1.70 | 75.8 ± 6.05 | 72.1 ± 7.73 | 71.3 ± 2.91 | 73.8 ± 1.92 | 59.7 ± 3.20 |
| Cholestrol (mmol/L) | 6.25 ± 0.13 | 6.19 ± 0.11 | 6.19 ± 0.39 | 5.97 ± 0.21 | 5.58 ± 0.16 | 5.51 ± 0.38 | 5.55 ± 0.52 | 5.72 ± 0.23 | 5.75 ± 0.11 | 5.10 ± 0.20 |
| HDL chol (mmol/L) | 1.34 ± 0.08 | 1.39 ± 0.06 | 1.40 ± 0.08 | 1.23 ± 0.10 | 1.35 ± 0.00 | 1.54 ± 0.13 | 1.27 ± 0.19 | 1.32 ± 0.04 | 1.33 ± 0.10 | 1.06 ± 0.09 |
| LDL chol (mmol/L) | 4.60 ± 0.09 | 4.50 ± 0.09 | 4.48 ± 0.26 | 4.52 ± 0.11 | 4.03 ± 0.13 | 3.70 ± 0.28 | 4.03 ± 0.31 | 4.15 ± 0.17 | 4.30 ± 0.07 | 3.58 ± 0.16 |
| Glucose (mmol/L) | 0.48 ± 0.11* | 0.33 ± 0.04* | 0.40 ± 0.07* | 0.40 ± 0.09* | 0.39 ± 0.05* | 0.25 ± 0.02* | 0.43 ± 0.11* | 0.35 ± 0.04* | 0.33 ± 0.01* | 1.17 ± 0.28 |
| Amylase (U/L) | 803 ± 55.3 | 769 ± 34.80 | 837 ± 35.50 | 807 ± 11.6 | 848 ± 35.2 | 809 ± 67.3 | 785 ± 12.0 | 751 ± 19.80 | 828 ± 7.77 | 810 ± 71.50 |
ALT/GPT – Alanine aminotransferase; AST/GOT – Aspartate aminotransferase Tot protein – total protein; Gamma GT – Gamma glutamyl transferase; HDL chol – high density lipoprotein cholesterol; LDL chol – low density lipoprotein cholesterol
*
p < 0.05 (statistically significant)