Fig. 5.

(A) Western blot analysis of different proteins such as p53, total and phospho ERK1/2, total and phospho p38, Bax, Bcl-2, Bcl-xL and cytochrome c. β-Actin served as a loading control. “a” indicates the significant difference between the normal and STZ-exposed rat liver tissue homogenates, “b” indicates the significant difference between STZ and CUR + STZ-treated liver tissue homogenates. Each column represents mean ± SEM, n = 6 (p^a < 0.05, p^b < 0.05). (B) Western blot analysis depicting the ultimate effects of CUR on STZ exposed mouse liver; caspase-3 activation and PARP cleavage in rat liver. β-Actin served as a loading control.