Table 2.
Haematology results (full blood count; mean ± SD) during the 72 h after drug administration.
| Group (n = 3) | Full blood count |
|||||||
|---|---|---|---|---|---|---|---|---|
| WCC | RCC | Hb | Hct | MCV | MCH | MCHC | Plt | |
| SAL (control) | ||||||||
| 24 h | 4.8 ± 0 | 6.2 ± 0 | 13.3 ± 0 | 0.388 ± 0 | 62.2 ± 2 | 21.1 ± 0 | 33.9 ± 1 | 970 ± 129 |
| 48 h | 6.0 ± 0 | 6.3 ± 0 | 12.9 ± 1 | 0.387 ± 0 | 61.8 ± 1 | 20.6 ± 0 | 33.4 ± 1 | 1023 ± 162 |
| 72 h | 4.9 ± 1 | 6.5 ± 0 | 13.0 ± 0 | 0.392 ± 0 | 60.5 ± 0 | 20.1 ± 0 | 33.3 ± 1 | 957 ± 88 |
| PAR-only | ||||||||
| 24 h | 4.1 ± 1 | 7.6 ± 0 | 15.2 ± 0 | 0.439 ± 0 | 57.6 ± 1 | 19.9 ± 0 | 34.5 ± 0 | 1159 ± 81 |
| 48 h | 5.9 ± 0 | 7.5 ± 0 | 15.3 ± 1 | 0.464 ± 0 | 61.1 ± 1 | 20.4 ± 0 | 33.1 ± 0 | 310 ± 305 |
| 72 h | 4.7 ± 1 | 6.8 ± 1 | 13.6 ± 2 | 0.406 ± 0 | 58.9 ± 4 | 19.8 ± 1 | 33.7 ± 1 | 326 ± 293 |
| PAR + GFJ low | ||||||||
| 24 h | 6.4 ± 1 | 6.7 ± 0 | 13.4 ± 1 | 0.397 ± 0 | 59.6 ± 1 | 20.0 ± 1 | 33.6 ± 0 | 1101 ± 172 |
| 48 h | 5.1 ± 1 | 6.1 ± 1 | 12.8 ± 3 | 0.387 ± 0 | 63.4 ± 1 | 20.9 ± 0 | 33.0 ± 0 | 333 ± 78 |
| 72 h | 6.1 ± 1 | 6.2 ± 1 | 12.4 ± 1 | 0.389 ± 0 | 62.3 ± 1 | 19.8 ± 0 | 31.9 ± 0 | 627 ± 59 |
| PAR + GFJ high | ||||||||
| 24 h | 6.2 ± 2 | 6.6 ± 0 | 13.7 ± 1 | 0.405 ± 0 | 61.0 ± 1 | 20.6 ± 0 | 33.7 ± 0 | 1088 ± 85 |
| 48 h | 4.7 ± 1 | 6.1 ± 0 | 13.0 ± 1 | 0.395 ± 0 | 64.5 ± 1 | 21.2 ± 1 | 33.0 ± 0 | 464 ± 74 |
| 72 h | 6.7 ± 0 | 6.6 ± 0 | 13.1 ± 0 | 0.399 ± 0 | 64.9 ± 2 | 21.3 ± 2 | 32.8 ± 0 | 492 ± 163 |
| PAR + BGT low | ||||||||
| 24 h | 4.5 ± 0 | 5.8 ± 0 | 11.6 ± 1 | 0.353 ± 0 | 61.0 ± 3 | 20.1 ± 1 | 33.0 ± 0 | 944 ± 185 |
| 48 h | 6.5 ± 0 | 6.4 ± 1 | 13.5 ± 2 | 0.420 ± 0 | 65.6 ± 2 | 21.0 ± 0 | 32.0 ± 0 | 587 ± 134 |
| 72 h | 5.4 ± 1 | 6.2 ± 1 | 12.8 ± 1 | 0.380 ± 0 | 61.6 ± 0 | 20.7 ± 0 | 33.6 ± 0 | 1065 ± 122 |
| PAR + BGT high | ||||||||
| 24 h | 7.0 ± 1 | 5.9 ± 1 | 12.4 ± 2 | 0.382 ± 0 | 64.4 ± 1 | 20.8 ± 1 | 30.6 ± 1 | 923 ± 68 |
| 48 h | 6.6 ± 1 | 6.4 ± 1 | 13.5 ± 1 | 0.392 ± 0 | 61.7 ± 3 | 21.1 ± 1 | 34.2 ± 1 | 773 ± 25 |
| 72 h | 5.6 ± 1 | 6.7 ± 1 | 13.5 ± 1 | 0.415 ± 0 | 62.3 ± 3 | 20.3 ± 1 | 32.6 ± 0 | 780 ± 119 |
PAR = paracetamol; GFJ = grapefruit juice; BGT = bergamottin; WCC = white cell count; RCC = red cell count, Hb = Haemoglobin; Hct = Haematocrit; MCV = mean corpuscular volume; MCH = mean corpuscular haemoglobin; MCHC = mean corpuscular haemoglobin concentration; Plt = platelets.