Fig. 3.

Photomicrographs of histological changes of rat liver at magnification of 10ÿ. (A) normal control showed well maintained histology of rat liver. (B) CCl₄ treated rats showed, fatty changes, necrosis, nuclear and lobular degeneration and inflammation of the cells. (C) LSE (100 mg/kg, p.o.) + CCl₄ (1.0 mL/kg in olive oil 1:1, i.p.) treated group showed less nuclear degeneration as compared to toxic group. (D) LSE (200 mg/kg, p.o.) + CCl₄ (1.0 mL/kg in olive oil 1:1, i.p.) treated rat liver showed improved structure with mild nuclear degeneration. (E) LSE (400 mg/kg, p.o.) + CCl₄ (1.0 mL/kg in olive oil 1:1, i.p.) treated rat liver showed minimum fatty acid changes and retain the general structure. (F) Silymarin (100 mg/kg, p.o.) + CCl₄ (1.0 mL/kg in olive oil 1:1, i.p.) treated rat liver showed preserved cell architecture. (G) Graph showing the level of deformity in each group. Scoring was performed as follows; scale: 1⿿100; 1: minimum deformity and 100: maximum deformity.