Table 4.
Summary of hematology, coagulation, and clinical chemistry values on day 15.
| Parameter | Males |
Females |
||
|---|---|---|---|---|
| 0 mL/kg | 10 mL/kg | 0 mL/kg | 10 mL/kg | |
| Hematology | ||||
| WBC (109/L) | 8.37 ± 1.27 | 9.22 ± 1.44 | 7.85 ± 1.30 | 6.70 ± 1.14* |
| RBC (1012/L) | 8.39 ± 0.20 | 8.52 ± 0.29 | 8.31 ± 0.21 | 8.22 ± 0.21 |
| HGB (g/L) | 157 ± 5 | 156 ± 4 | 156 ± 5 | 154 ± 4 |
| HCT (L/L) | 0.526 ± 0.011 | 0.529 ± 0.014 | 0.514 ± 0.017 | 0.510 ± 0.015 |
| MCV (fL) | 62.7 ± 0.8 | 62.1 ± 0.8 | 61.8 ± 0.9 | 62.1 ± 1.2 |
| MCH (pg) | 18.7 ± 0.6 | 18.3 ± 0.5 | 18.8 ± 0.3 | 18.7 ± 0.2 |
| MCHC (g/L) | 298 ± 7 | 295 ± 5 | 304 ± 4 | 302 ± 4 |
| Plat (109/L) | 1088 ± 73 | 1071 ± 91 | 1036 ± 95 | 1110 ± 124 |
| Neut (%) | 10.0 ± 3.2 | 10.8 ± 2.9 | 7.8 ± 1.3 | 9.5 ± 1.9* |
| Lymp (%) | 86.0 ± 3.7 | 85.0 ± 3.0 | 87.5 ± 2.8 | 86.2 ± 2.1 |
| Mono (%) | 1.8 ± 0.5 | 2.0 ± 0.4 | 2.5 ± 2.2 | 2.1 ± 1.6 |
| Eosi (%) | 0.6 ± 0.6 | 0.6 ± 0.5 | 0.6 ± 0.2 | 0.7 ± 0.2 |
| Baso (%) | 0.5 ± 0.3 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 |
| Neut A (109/L) | 0.81 ± 0.16 | 1.01 ± 0.34 | 0.62 ± 0.15 | 0.65 ± 0.22 |
| Lymp A (109/L) | 7.23 ± 1.34 | 7.83 ± 1.24 | 6.85 ± 0.95 | 5.77 ± 0.97* |
| Mono A (109/L) | 0.14 ± 0.03 | 0.18 ± 0.04* | 0.22 ± 0.25 | 0.14 ± 0.08 |
| Eosi A (109/L) | 0.05 ± 0.04 | 0.05 ± 0.04 | 0.04 ± 0.01 | 0.04 ± 0.01 |
| Baso A (109/L) | 0.04 ± 0.03 | 0.03 ± 0.01 | 0.03 ± 0.01 | 0.02 ± 0.01 |
| Coagulation | ||||
| PT (s) | 16.9 ± 1.2 | 17.2 ± 0.6 | 17.7 ± 0.5 | 18.5 ± 0.6* |
| APTT (s) | 14.2 ± 2.2 | 13.7 ± 2.8 | 12.2 ± 1.5 | 11.6 ± 2.9 |
| Clinical chemistry | ||||
| Glu (mmol/L) | 7.44 ± 0.73 | 7.16 ± 0.60 | 6.87 ± 0.54 | 7.12 ± 0.32 |
| BUN (mmol/L) | 3.94 ± 0.36 | 4.58 ± 0.94* | 5.92 ± 0.81 | 5.11 ± 0.65* |
| Creat (μmol/L) | 24 ± 9 | 21 ± 4 | 25 ± 8 | 21 ± 6 |
| AST (U/L) | 93 ± 17 | 92 ± 11 | 94 ± 9 | 94 ± 6 |
| ALT (U/L) | 61 ± 11 | 55 ± 6 | 49 ± 6 | 50 ± 4 |
| GGT (U/L) | 0 ± 1 | 1 ± 1 | 2 ± 1 | 1 ± 1 |
| ALP (U/L) | 177 ± 10 | 180 ± 16 | 117 ± 17 | 120 ± 15 |
| T. Bil (μmol/L) | 1.70 ± 0.78a | 1.50 ± 0.54 | 1.25 ± 0.58b | 0.91 ± 0.28b |
| T. Chol (mmol/L) | 3.34 ± 0.15 | 3.41 ± 0.27 | 3.49 ± 0.17 | 3.49 ± 0.20 |
| Trig (mmol/L) | 0.74 ± 0.11 | 0.71 ± 0.08 | 0.66 ± 0.16 | 0.59 ± 0.06 |
| T. Pro (gL) | 64.1 ± 1.8 | 69.4 ± 4.8* | 70.8 ± 1.6 | 66.9 ± 1.2* |
| Alb (g/L) | 41.0 ± 1.3 | 40.4 ± 1.2 | 40.2 ± 2.8 | 41.7 ± 0.8* |
| Pi (mmol/L) | 2.95 ± 0.11 | 2.78 ± 0.19* | 2.44 ± 0.17 | 2.37 ± 0.10 |
| Ca (mmol/L) | 2.47 ± 0.11 | 2.32 ± 0.11* | 2.43 ± 0.21 | 2.48 ± 0.10 |
| Na (mEq/L) | 149.4 ± 1.7 | 150.5 ± 0.7 | 148.4 ± 1.5 | 149.3 ± 1.8 |
| K (mEq/L) | 3.90 ± 0.21 | 3.86 ± 0.24 | 3.47 ± 0.26 | 3.47 ± 0.21 |
WBC, white blood corpuscles; RBC, red blood corpuscles; HGB, haematoglobin; HCT, haematocrit; MCV, mean corpuscular volume; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; Plat, platelets; Neut, neutrophils; Lymp, lymphocytes; Mono, monocytes; Eosi, eosinophils; Baso, basophils; PT, prothrombin time; APTT, activated partial thromboplastin time; Glu, glucose; BUN, blood urea nitrogen; Creat, creatine; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transpeptidase; ALP, alkaline phosphatase; T. Bil, total bilirubin; T. Chol, total cholesterol; Trig, triglycerides; T. Pro, total plasma protein; Alb, albumin; Pi, inorganic phosphorous; Ca, calcium; Na, sodium; K, potassium.
Data are presented as mean values ± standard deviations with N = 10.
* Statistically significant from the vehicle control group (P ≤ 0.05).
N = 8 (two values below the lower limit of Quantification for T. Bil (0.40 μmol/L) were not considered for analysis).
N = 9 (one value below the lower limit of Quantification for T. Bil (0.40 μmol/L) was not considered for analysis).