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. 2015 Feb 17;2:806–816. doi: 10.1016/j.toxrep.2015.02.008

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 6 — Effect of 30 min preincubation (with and without NADPH regenerating system) of extent of inhibition of CYP3A4 mediated testosterone 6′-hydroxylation by alcoholic (a) and aqueous extract (b) of T. arjuna; inhibition of CYP2D6 mediated dextromethorphan O-demethylation by alcoholic (c) and aqueous (d) extract of T. arjuna; inhibition of CYP2C9 mediated diclofenac 4′-hydroxylation by alcoholic (e) and aqueous (f) extract of T. arjuna ( – preincubation for 30 min with NADPH regenerating system, ■ – preincubation for 30 min without NADPH regenerating system, – no preincubation).

Inline graphic — Effect of 30 min preincubation (with and without NADPH regenerating system) of extent of inhibition of CYP3A4 mediated testosterone 6′-hydroxylation by alcoholic (a) and aqueous extract (b) of T. arjuna; inhibition of CYP2D6 mediated dextromethorphan O-demethylation by alcoholic (c) and aqueous (d) extract of T. arjuna; inhibition of CYP2C9 mediated diclofenac 4′-hydroxylation by alcoholic (e) and aqueous (f) extract of T. arjuna ( – preincubation for 30 min with NADPH regenerating system, ■ – preincubation for 30 min without NADPH regenerating system, – no preincubation).