Table 1.
IC50 values of alcoholic and aqueous extracts of T. arjuna, arjunic acid, arjunetin and arjungenin for CYP3A4, CYP2D6 and CYP2C9 enzymes in HLM.
| Enzyme | IC50 values |
||||
|---|---|---|---|---|---|
| Alcoholic extract of T. arjuna (μg of extract/mL) | Aqueous extract of T. arjuna (μg of extract/mL) | Arjunic acid | Arjunetin | Arjungenin | |
| CYP3A4 | 16.6 ± 6.5 | 17.4 ± 2.7 | >50 μM (>25 μg/ml) | >50 μM (>33 μg/ml) | >50 μM (>25 μg/ml) |
| CYP2D6 | 15.28 ± 4.16 | 11.97 ± 14.6 | >50 μM (>25 μg/ml) | >50 μM (>33 μg/ml) | >50 μM (>25 μg/ml) |
| CYP2C9 | 34.52 ± 3.2 | 27.78 ± 2.4 | >50 μM (>25 μg/ml) | >50 μM (>33 μg/ml) | >50 μM (>25 μg/ml) |
IC50 values, 50% inhibitory concentration. Data represent the mean of triplicate.