Fig. 3.

Time-dependent profiles of four sulfur mustard-DNA adducts in urine samples from exposed individuals. An isotope-dilution ultrahigh performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) combining with solid phase extraction was performed to simultaneously detect the four DNA adducts which include N⁷-HETEG, Bis-G, N³-HETEG and O⁶-HETEG in urine samples. (a) Patient 1; (b) patient 2; (c) patient 3; (d) patient 4. Results are showed for determinations performed once due to the limited sample volume.