Table 1.
Effect of cleistanthins A and B on blood pressure and heart rate of male Wistar rat.
| Group | Systolic AUC | Diastolic AUC | Mean AUC | Heart rate AUC | Systolic % changes (mmHg) | Diastolic % changes (mmHg) | Mean % changes (mmHg) |
|---|---|---|---|---|---|---|---|
| Control | 4563.75 ± 227.93 | 3408.75 ± 234.30 | 3772.50 ± 201.38 | 18,626.25 ± 1831.30 | −16.89 ± 7.21 | 19.06 ± 4.59 | 5.57 ± 4.37 |
| Cleistanthin A 12.5 mg/kg | 4905.00 ± 201.97 | 3977.50 ± 156.97 | 4233.75 ± 191.22 | 17,142.50 ± 1544.47 | −1.83 ± 9.41 | 35.14 ± 3.80 | 22.94 ± 5.53 |
| Cleistanthin A 25 mg/kg | 4245.00 ± 713.78 | 2865.00 ± 453.04 | 3310.00 ± 533.18 | 15,325.00 ± 2784.91 | 6.26 ± 6.92 (n = 5) | 25.32 ± 4.17 (n = 5) | 18.28 ± 5.18 (n = 5) |
| Cleistanthin A 50 mg/kg | 4591.25 ± 269.26 | 3227.50 ± 228.86 | 3742.50 ± 173.36 | 16,855.00 ± 888.99 | 2.14± 8.83 (n = 5) | 21.77 ± 7.47 (n = 5) | 16.63 ± 6.33 (n = 5) |
| Cleistanthin B 12.5 mg/kg | 4416.25 ± 292.71 | 2921.25 ± 310.56 | 3362.50 ± 328.66 | 9417.50 ± 1746.90 | 8.99± 3.58 (n = 5) | 27.24 ± 7.16 (n = 5) | 20.39 ± 5.15 (n = 5) |
| Cleistanthin B 25 mg/kg | 4683.75 ± 567.70 | 3291.25 ± 456.68 | 3938.75 ± 401.75 | 12,877.50 ± 2214.42 | 4.06 ± 7.60 (n = 5) | 23.27 ± 5.40 (n = 5) | 16.17 ± 5.62 (n = 5) |
| Cleistanthin B 50 mg/kg | 5240.00 ± 375.65 | 3020.00 ± 364.65 | 4055.00 ± 272.62 | 19,711.25 ± 1582.22 | 5.37 ± 4.10 (n = 5) | 24.11 ± 5.77 (n = 5) | 17.59 ± 5.42 (n = 5) |
The values are mean ± SEM; n = 6 in each group. The % change was calculated using pre-study values and 90th day values. One-way ANOVA followed by Bonferroni test. No group showed significant differences.