Table 7.
Drug and dose | Number of animals died |
Description | |
---|---|---|---|
M (n = 6) | F (n = 6) | ||
Control (0.5% CMC) | 0 | 0 | |
Cleistanthin A 12.5 mg/kg | 0 | 0 | |
Cleistanthin A 25 mg/kg | 1 | 0 | Male rate died on 14th day |
Cleistanthin A 50 mg/kg | 0 | 0 | |
Cleistanthin A 100 mg/kg | 2 | 2 | Male rats died on 28th and 30th day and female rats died on 25th and 30th day |
Cleistanthin A 200 mg/kg | 2 | 2 | Male rats died on 10th and 12th day and female rats died on 7th and 14th day |
Cleistanthin A 400 mg/kg | 2 | 3 | Male rats died on 4th and 6th day and female rats died on 4th, 5th and 6th day |