Table 9.

Histopathological summary report of cleistanthin A.

Treatment	Organ	Male	Female
Control		Normal	Normal
Cleistanthin A 12.5 mg/kg	Brain	Normal	↑ Corpora amylacea
	Lung	Interstitial pneumonitis	Severe interstitial pneumonitis
	Heart	Normal	Normal
	Liver	Normal	Normal
	Stomach	Normal	Normal
	Kidney	Normal	Acute tubular necrosis
	Bone marrow	Normal	Normal
Cleistanthin A 25 mg/kg	Brain	↑ Corpora amylacea	↑ Corpora amylacea
	Lung	Inflammation in lung; Interstitial pneumonitis (↑↑) and collapse of alveolar air spaces	Severe interstitial pneumonitis
	Heart	Normal	Normal
	Liver	Normal	Normal
	Stomach	Normal	Normal
	Kidney	Normal	Acute tubular necrosis
	Bone marrow	Normal	Normal
Cleistanthin A 50 mg/kg	Brain	↑ Corpora amylacea	↑ Corpora amylacea
	Lung	Severe interstitial pneumonitis, crystalline deposition and foreign body giant cell	Severe interstitial pneumonitis, crystalline deposition and foreign body giant cell reaction
	Heart	Normal	Normal
	Liver	Normal	Normal
	Stomach	Normal	Normal
	Kidney	Normal	Acute tubular necrosis
	Bone marrow	Normal	Normal