Fig. 5.

Pathological and pro-inflammatory changes in the BALF of ricin intoxicated mice following treatment with α-ricin antibodies or with α-ricin antibodies and doxycycline. Mice were intranasally exposed to 7 μg/kg ricin and subjected to different treatment modes. (A) Ricin-intoxicated mice were treated with doxycycline immediately after intoxication and BALF collected at 72 h was monitored for IL-1β, IL-6, VEGF, ChE and XO. (B) Ricin-intoxicated mice were treated with doxycycline and/or anti-ricin antibodies and BALF collected at 72 h was monitored for MMP-9. (C) Ricin-intoxicated mice were treated with doxycycline and lungs were harvested at 72 h PE and weighed. Wet lung weight is presented as percent of total body weight. Error bars represent the standard error of the mean of the samples. *p < 0.05 in comparison to non-treated mice. N = 5.