Table 1.

Parameters of the coronary flow under basal conditions and during reperfusion after global ischemia of different durations.

Parameter	Group (treatment)	Determination of coronary flow
		Basal conditions (before ischemia)
Coronary flow (ml/min)	Control	9.76 ± 0.70c, *
	Cisplatin	6.76 ± 0.60a, *
	Cisplatin + NAC	7.75 ± 0.26
		During reperfusion
		30 s ischemia	1 min ischemia	2 min ischemia
Total overflow after ischemia of different duration (% of increase comparing to basal CF values)	Control	22.35 ± 5.15	39.19 ± 10.34	72.43 ± 17.25
	Cisplatin	7.38 ± 4.88a, *	12.00 ± 5.02a, *	8.61 ± 6.70a, *
	Cisplatin + NAC	34.22 ± 2.86b, **	68.83 ± 6.34b, **	103.33 ± 13.07b, **
Maximal overflow after ischemia of different duration (% of increase comparing to basal CF values)	Control	17.30 ± 1.31c, *	24.59 ± 4.65	26.25 ± 4.48c, *
	Cisplatin	5.64 ± 2.56a, *	9.03 ± 2.27a, *	5.41 ± 3.63a, *
	Cisplatin + NAC	22.63 ± 1.69b, **	36.76 ± 0.87b, **	42.55 ± 1.43b, **
Duration of overflow after ischemia of different duration (in minutes)	Control	2.00 ± 0.32	2.60 ± 0.60c, *	4.00 ± 0.63
	Cisplatin	0.80 ± 0.37a, *	1.80 ± 0.90	1.00 ± 0.71a, *
	Cisplatin + NAC	2.50 ± 0.29b, *	4.50 ± 0.29b, **	4.75 ± 0.25b, *

Values are expressed as mean ± S.E.M. for eight animals.

^aControl vs. cisplatin.

^bCisplatin vs. cisplatin + NAC.

^cControl vs. cisplatin + NAC.

^*p < 0.05.

^**p < 0.01.