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. 2015 May 11;2:654–663. doi: 10.1016/j.toxrep.2015.05.001

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© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Fig. 4 — (a) Photograph of the skeletal system of 20 days old control fetus showing: well ossified skull (S), cervical (CRV), thoracic (THV), lumbar (LV), sacral (SV), caudal vertebrae (CV) and hind limbs (HL). (b) Photograph of fetus maternally treated with imatinib (36 mg/kg) from 6th to 13th day of gestation showing: retardation of ossification of skull (S), upper jaw (UJ), Lower jaw (LJ) and presence of wavy ribs (WR). (c) Skeleton of fetuses maternally treated with imatinib (36 mg/kg) from 13th to 19th of gestation showing incomplete ossification of cervical (CRV), thoracic vertebrae (THV), metacarpals (MC), metatarsals (MT) and phalanges (PH). Absence of the last rib (LR) (no. 13) and a fetus had wavy ribs (WR) (nos. 7, 8, and 9). (d) Skeleton of fetuses on the 20th day of gestation maternally treated with imatinib (54 mg/kg) from 6th to 13th day of gestation showing sever lack of ossification of scapulae (SC) and clavicles (Cl) bones of the pectoral girdle (PG). Lack of ossification of pelvic girdle (PLG) and humerus (HU), radius (RA), ulna (UL), metacarpals (MC) and phalanges (PH) of the fore limb (FL). Femur (FE), tibia (TI), fibula (FI), metatarsals (MT) and phalanges (PH) of the hind limb (HL) showed lower degree of ossification, shorter and thinner as compared to the control fetus (a). (e) Severe lack of ossification of cervical (CRV), thoracic vertebrae (THV), lumbar vertebrae (LV) and sacral vertebrae (SV). Severe rib anomalies: wavy ribs (WR) on rib numbers 7, 8, and 9 and absence of the last rib (LR) number 13.