Table 1.
Average weights of uteri and placenta of pregnant rats at the 20th day of gestation.
| Groups | Total no. of pregnant rats | Total number of sacrificed uteri | Uteri |
Placenta |
|||||
|---|---|---|---|---|---|---|---|---|---|
| Without resorption C% | With partial resorption C% | With complete resorption C% | Average weight of uteri | C% | Average weight of placenta | C% | |||
| Control | 8 | 8 | 8 (100) | – | – | 35.52 ± 0.70 | – | 1.53 ± 0.08 | – |
| Imatinib low dose (6th–13th) | 8 | 6 | 6 (75) | – | – | 24.41 ± 3.23 | 11.11 (−31.28) | 1.0 ± 0.15 a*e* |
−34.64 |
| Imatinib low dose (13th–19th) | 8 | 8 | 3 (37.5) | 5 (62.5) | – | 22.76 ± 4.87 a* |
12.76 (−35.92) | 0.87 ± 0.17 a** |
−43.13 |
| Imatinib high dose (6th–13th) | 8 | 5 | 4 (50) | – | 1 (12.5) | 16.06 ± 4.36 a** |
19.46 (−54.78) | 0.62 ± 0.13 a*** |
−59.47 |
| Imatinib high dose (13th–19th) | 8 | 6 | 1 (12.5) | 5 (62.5) | – | 15.28 ± 5.69 a*** |
20.24 (−56.98) | 0.53 ± 0.18 a***b* |
−65.35 |
Values are means (±SE) of 8 animals.
a = compared to the normal control.
b = compared to the low dose of imatinib (36 mg/kg) from 6th to 13th day of gestation.
c = compared to the low dose of imatinib (36 mg/kg) from 13th to 19th day of gestation.
d = compared to the high dose of imatinib (54 mg/kg) from 6th to 13th day of gestation.
e = compared to the high dose of imatinib (54 mg/kg) from 13th to 19th day of gestation.
C% = percentage of change from normal control.
*
Significant (p < 0.05).
**
Highly significant (p < 0.01).
***
Very highly significant (p < 0.001).