Table 2.
Changes in body weight, liver weight, plasma clinical parameters, and lipid concentration in plasma and liver of mice treated with CFE.
| CFE-treated |
|||
|---|---|---|---|
| Control (0%) | 0.3% | 1% | |
| Final body weight (g) | 36.0 ± 0.93 [1.0] | 34.5 ± 0.46 [0.96] | 33.6 ± 0.65 [0.93] |
| Liver weight (% body weight) | 4.33 ± 0.18 [1.0] | 5.91 ± 0.27 [1.4]* | 8.60 ± 0.40 [2.0]* |
| Plasma clinical parameters | |||
| AST (IU/L) | 48.0 ± 7.5 [1.0] | 113.4 ± 32.6 [2.4] | 160.0 ± 45.7 [3.3] |
| ALT (IU/L) | 17.0 ± 2.2 [1.0] | 64.2 ± 21.3 [3.8] | 100.6 ± 42.9 [5.9] |
| ALP (IU/L) | 264 ± 35 [1.0] | 380 ± 72 [1.4] | 512 ± 77 [1.9]* |
| Plasma lipids | |||
| Triglyceride (mg/dL) | 102 ± 19.0 [1.0] | 99 ± 28.2 [1.0] | 208 ± 34.6 [2.0]* |
| Cholesterol (mg/dL) | 208 ± 9.6 [1.0] | 146 ± 24.3 [0.7] | 189 ± 26.9 [0.9] |
| Phospholipid (mg/dL) | 277 ± 14.0 [1.0] | 214 ± 31.6 [0.8] | 268 ± 26.9 [1.0] |
| Non-esterified fatty acid (mequiv./L) | 1.49 ± 0.39 [1.0] | 1.23 ± 0.37 [0.8] | 1.85 ± 0.31 [1.2] |
| Hepatic lipids | |||
| Triglyceride (mg/g liver) | 14.1 ± 1.2 [1.0] | 32.9 ± 2.7 [2.3]* | 45.2 ± 4.9 [3.2]* |
| Cholesterol (mg/g liver) | 7.1 ± 0.51 [1.0] | 12.1 ± 1.5 [1.7]* | 13.4 ± 1.1 [1.9]* |
| Phospholipid (mg/g liver) | 13.9 ± 0.87 [1.0] | 13.1 ± 1.1 [0.95] | 13.4 ± 1.5 [0.97] |
Male ICR mice were maintained for 2 weeks on a diet supplemented with 0% CFE (control), 0.3% CFE, or 1% CFE. Each value is the mean and SE from 5 mice. Numbers in brackets indicate the ratio compared to the control group.
*
Significant difference from the level of control group is indicated by p < 0.05.