Fig. 2.

Prospective role of C1P in TNFα production via direct inhibition of TACE. ADAM17/ TACE is the major metalloprotease responsible for cleaving or “shedding” mature TNFα (pro-TNFα) to release the active soluble form. Recent studies have demonstrated a direct interaction between C1P and TACE, which inhibits the sheddase activity and hinders the ability of TACE to release active TNFα. Current investigations are focused on identifying the TACE residues that mediate the interaction of the enzyme with C1P