Table 8.
Selected resistance profile of inhibitor 38
| Virusa | IC50 values, nM (fold change) | |||||
|---|---|---|---|---|---|---|
|
|
||||||
| 38 | ATV | APV | SQV | IDV | DRV | |
| HIV-1HXB2 (WT) | 0.7 | 25 | 130 | 60 | 50 | 3.9 |
| HIV-1D545701 (MDR) | 4.8 (7) | 70 (3) | >1000 (>8) | 603 (10) | 440 (9) | 32 (8) |
| HIV-1EP13 (MDR) | 1.1 (2) | 93 (4) | 440 (3) | 80 (1.3) | 330 (7) | 6.8 (2) |
a
Amino acid substitutions in the protease-encoding region compared to type B: L10I, L19Q, K20R, E35D, M36I, S37N, M46I, I50V, I54V, I62V, L63P, A71V, V82A, L90M in HIV-1D545701; M46I, L63P, A71V, V82F, I84V in HIV-1EP13