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. 2014 Jul 7;1:360–372. doi: 10.1016/j.toxrep.2014.06.006

Fig. 1.

Fig. 1

Gene expression in KGN cells after a 24-h exposure to various phytoestrogens. (A) CYP19A1 mRNA levels. Significant up-regulation of CYP19A1 mRNA after exposure to 8-PN (3 μM), GEN (10 μM) and QUE (10 μM). PGE2 (0.1 μM) was used as a positive control. (B) Promoter P1.3- and PII-specific expression of CYP19A1 mRNA. Significant up-regulation of PI.3 and PII – driven CYP19A1 mRNA after exposure to 8-PN (3 μM), GEN (10 μM) and QUE (10 μM). PGE2 (0.1 μM) was used as a positive control. Data are expressed as fold-change compared with expression in vehicle-control treated cells. Bars represent mean + SD of three independent experiments that were performed in triplicate (N = 3). * and # significantly from relevant solvent vehicle control Ethanol (0.1%) or DMSO (0.1%)-treated cells, respectively. P < 0.05.