Table 3.
Effect of artesunate 45 days treatment on biochemical parameter of rats.
| Treatment group (mg/kg/day, p.o) | SGOT (IU/L) | SGPT (IU/L) | ALP (IU/L) | TC (mg/dl) | TG (mg/dl) | TP (g/dl) | Albumin (g/dl) | Total bilirubin (mg/dl) | Creatinine (mg/dl) | Urea (mg/dl) | Glucose (g/dl) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Vehicle control | 27.70 ± 2.20 | 14.91 ± 1.31 | 110.30 ± 4.03 | 175.78 ± 10.33 | 105.35 ± 7.36 | 7.70 ± 1.02 | 3.90 ± 0.65 | 0.99 ± 0.06 | 0.68 ± 0.02 | 4.35 ± 0.93 | 110.93 ± 5.63 |
| Artesunate (2) | 28.66 ± 2.49ns | 26.62 ± 2.76a | 213.15 ± 9.65c | 255.64 ± 13.10b | 168.17 ± 9.82b | 8.15 ± 1.96ns | 4.30 ± 0.96ns | 1.76 ± 0.21ns | 0.85 ± 0.01ns | 4.49 ± 0.33ns | 105.32 ± 4.96ns |
| Artesunate (4) | 41.39 ± 2.78a | 37.58 ± 2.86c | 285.82 ± 8.66c | 277.99 ± 12.75c | 178.95 ± 10.05c | 9.11 ± 1.14ns | 2.77 ± 0.26ns | 2.13 ± 0.42ns | 1.08 ± 0.21ns | 4.27 ± 0.67ns | 125.75 ± 6.33ns |
| Artesunate (8) | 62.64 ± 3.75c | 51.62 ± 2.77c | 362.31 ± 1.19c | 285.18 ± 15.06c | 245.36 ± 12.09c | 9.27 ± 1.06ns | 1.80 ± 0.63ns | 3.73 ± 0.96a | 1.14 ± 0.19ns | 4.39 ± 0.85ns | 144.97 ± 8.42b |
n = 6. ns = not significant when compared to vehicle control group, SGOT = serum glutamate oxaloacetate transminase, SGPT = serum glutamate pyruvate transminase, ALP = alkaline phosphate, TC = total cholesterol, TG = triglyceride and TP = total protein.
a
p < 0.05.
b
p < 0.01.
c
p < 0.001.