Table 4.
Hematological parameters after a 28-day treatment with the methanol extract of stem bark of Amphimas pterocarpoides in male Wistar rats.
| Parameters | Historical ranges | Control |
A. pterocarpoides (mg/kg BW) |
Satellite groups |
|||
|---|---|---|---|---|---|---|---|
| 150 | 300 | 600 | Control SAT | 600 SAT | |||
| WBC (×103 μL−1) | 5–16 | 15.58 ± 2.65 | 14.84 ± 2,18 | 15.96 ± 2.23 | 17.32 ± 4.78 | 13.38 ± 1.92 | 3.55 ± 0.35** |
| Lymphocytes (%) | 65–85 | 68.58 ± 2.27 | 68.04 ± 2,85 | 64.30 ± 2.23 | 70.18 ± 1.42 | 76.78 ± 1.19 | 89.33 ± 1.26** |
| Monocytes (%) | 0–20 | 19.66 ± 1.12 | 18.60 ± 1,18 | 20.96 ± 1.36 | 16.28 ± 1.27 | 14.10 ± 1.70 | 8.40 ± 0.45** |
| Granulocytes (%) | 0–27 | 11.78 ± 1.33 | 13.38 ± 1,55 | 14.74 ± 1.46 | 13.54 ± 1.53 | 11.60 ± 0.76 | 2.48 ± 0.53** |
| RBC (×103 μL−1) | 5–10 | 7.30 ± 0.31 | 6.71 ± 0,88 | 7.53 ± 0.30 | 7.65 ± 1.21 | 7.00 ± 0.48 | 5.47 ± 0.48 |
| Hematocrit (%) | 32–53 | 38.94 ± 1.26 | 35.66 ± 3,55 | 38.92 ± 1.33 | 39.82 ± 6.08 | 36.70 ± 4.46 | 27.03 ± 2.34 |
| MCV (fL) | 52–59 | 53.40 ± 0.81 | 54.80 ± 2,85 | 51.60 ± 0.81 | 52.20 ± 1.32 | 57.25 ± 3.95 | 49.80 ± 0.48 |
| Platelets (×103 μL−1) | 200–1100 | 317.60 ± 23.26 | 266.80 ±17,50 | 328.40 ± 15.07 | 419.60 ± 22.75** | 271.00 ± 24,46 | 72.67 ± 4.06** |
| MCH (pg) | 17–27 | 18.88 ± 0.27 | 21.12 ± 2,86 | 18.18 ± 0.40 | 17.74 ± 0.61 | 24.02 ± 2.23 | 19.13 ± 0.18 |
| Hemoglobin (g/dL) | 12–18 | 13.76 ± 0.48 | 13.16 ± 0,61 | 13.68 ± 0.48 | 13.68 ± 2.46 | 12.62 ± 1.49 | 10.40 ± 0.83 |
| MCHC (g/dL) | 32–45 | 35.34 ± 0.34 | 38.02 ± 0,97 | 35.18 ± 0.97 | 34.00 ± 0.77 | 41.34 ± 0.84 | 38.53 ± 0.26 |
WBC: white blood cells; RBC: red blood cells; MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHM: mean corpuscular hemoglobin concentration. Control SAT: satellite control treated with vehicle; 600 SAT: satellite of top dose treated with AP at 600 mg/kg BW.
Data are represented as mean ± SEM (n = 5).
**p < 0.01 significantly different as compared to control groups.