Fig. 1.

(A) A schematic indicating the timing of treatments, initiation of diet changes and analyses. (B and C) Mice, n = 6⿿9 mice/treatment/sex/diet, were euthanized and the BW and pericardial fat weighed. Body surface area was calculated from the BW at euthanasia. Data are expressed as mean ± SEM. Significance, indicated by p < 0.05 when compared with ^* VEH and ^⿠ control diet. (D) Mice, n = 8⿿9/treatment/sex, were anesthetized mice and ECG data collected after IP isoproterenol injection. Heart rate (HR), P wave duration (P-dur), QRS and QT corrected for HR (QTc) are plotted with time. The arrow indicates peak HR. Data are the mean ± SEM. Significance, indicated by p < 0.05 when compared with ^* VEH.