Table 1.
Mean liver weight parameters for male rats treated with either 0, 0.1, 1 or 50 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate and female rats treated with either 0, 1, 50 or 500 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate for 12 (interim sacrifice) and 24 (terminal sacrifice) months.
| Mean liver weights at interim and terminal sacrifice in male and female rats | ||||||||
|---|---|---|---|---|---|---|---|---|
| Males | ||||||||
| Interim sacrifice | Terminal sacrifice | |||||||
| Dose level (mg/kg) | 0 | 0.1 | 1 | 50 | 0 | 0.1 | 1 | 50 |
| N | 10 | 10 | 10 | 10 | 15 | 20 | 18 | 18 |
| Absolute (g) | 26.9 ± 4.9* | 26.1 ± 4.3 | 25.5 ± 1.9 | 29.7 ± 5.0 | 24.3 ± 3.6 | 26.6 ± 6.4 | 24.1 ± 5.6 | 27.1 ± 4.8 |
| % | −3% | −5% | 10% | 9% | −1% | 12% | ||
| Liver/body weight (%) | 3.2 ± 0.3 | 3.3 ± 0.3 | 3.3 ± 0.2 | 3.7 ± 0.4# | 2.9 ± 0.4 | 3.3 ± 1.3 | 3.2 ± 0.7 | 3.2 ± 0.5 |
| % | 3% | 3% | 16% | 14% | 10% | 10% | ||
| Females | ||||||||
|---|---|---|---|---|---|---|---|---|
| Interim sacrifice | Terminal sacrifice | |||||||
| Dose level (mg/kg) | 0 | 1 | 50 | 500 | 0 | 1 | 50 | 500 |
| N | 10 | 10 | 10 | 10 | 16 | 22 | 15 | 18 |
| Absolute (g) | 13.2 ± 2.5 | 12.0 ± 1.6 | 14.8 ± 3.6 | 17.6 ± 2.6# | 16.4 ± 3.8 | 15.8 ± 4.3 | 17.2 ± 3.0 | 23.2 ± 8.2# |
| % | −9% | 12% | 33% | −4% | 5% | 41% | ||
| Liver/body weight (%) | 2.9 ± 0.3 | 3.0 ± 0.3 | 3.3 ± 0.4 | 4.9 ± 0.6# | 3.5 ± 0.4 | 3.3 ± 0.7 | 3.3 ± 0.6 | 5.0 ± 0.9# |
| % | 3% | 14% | 69% | −6% | −6% | 43% | ||
#
Significantly different from control (p < 0.01). %Indicates difference from controls.
*
Mean ± standard deviation.