Table 3.
Test substance-associated non-neoplastic histological lesions in the liver of male rats treated with either 0, 0.1, 1 or 50 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate and female rats treated with either 0, 1, 50 or 500 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate for 24 months, N = 70.
| Summary of test substance-associated non-neoplastic findings in the liver of male and female rats: terminal sacrifice | ||||
|---|---|---|---|---|
| Males | ||||
| Dose level (mg/kg) | 0 | 0.1 | 1 | 50 |
| Degeneration, cystic, focal | 24 | 24 | 19 | 42* |
| Hypertrophy, hepatocyte, centrilobular | 0 | 0 | 0 | 7* |
| Necrosis, hepatocytes, centrilobular | 1 | 0 | 1 | 5* |
| Females | ||||
| Dose level (mg/kg) | 0 | 1 | 50 | 500 |
| Degeneration, cystic, focal | 2 | 2 | 2 | 14* |
| Hypertrophy, hepatocyte, centrilobular | 0 | 0 | 3 | 65* |
| Hypertrophy, hepatocyte, panlobular | 0 | 0 | 0 | 3* |
| Necrosis, hepatocytes, centrilobular | 1 | 1 | 4 | 7* |
| Necrosis, individual hepatocyte | 0 | 0 | 0 | 3* |
*
Significantly different from control (p < 0.05).