Table 4.
Test substance-associated non-neoplastic histological lesions in the kidney of female rats treated with either 0, 1, 50 or 500 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate for 24 months, N = 70.
| Summary of test substance-associated non-neoplastic findings in the kidneys of female rats: terminal sacrifice | ||||
|---|---|---|---|---|
| Dose level (mg/kg) | 0 | 1 | 50 | 500 |
| Dilation, tubular | 4 | 2 | 5 | 28* |
| Edema, papilla | 4 | 1 | 2 | 43* |
| Hyperplasia, transitional cell | 6 | 3 | 12 | 33* |
| Mineralization, tubular | 25 | 32 | 28 | 42* |
| Necrosis, papillary | 0 | 0 | 0 | 16* |
| Nephropathy, chronic progressive | 39 | 40 | 41 | 64* |
*
Significantly different from control (p < 0.05).