Table 5.
Test substance-associated non-neoplastic histological lesions in the nonglandular stomach and tongue of female rats treated with either 0, 1, 50 or 500 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate for 24 months, N = 70.
| Summary of test substance-associated non-neoplastic findings in the nonglandular stomach and tongue of female rats: terminal sacrifice | ||||
|---|---|---|---|---|
| Dose level (mg/kg) | 0 | 1 | 50 | 500 |
| Stomach, nonglandular | ||||
| Hyperplasia, epithelial, limiting ridge | 0 | 0 | 0 | 9* |
| Tongue | ||||
| Hyperplasia, squamous cell | 2 | 8 | 4 | 13* |
| Inflammation, subacute/chronic | 3 | 8 | 4 | 13* |
*
Significantly different from control (p < 0.05).