Table 6.
Test substance-associated neoplastic histological lesions in the liver, pancreas and testes of male rats treated with either 0, 0.1, 1 or 50 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate and the liver and pancreas of female rats treated with either 0, 1, 50 or 500 mg/kg ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate for 24 months, N = 70.
| Summary of test substance-associated neoplastic findings in male and female rats: terminal sacrifice | ||||
|---|---|---|---|---|
| Males | ||||
| Dose level (mg/kg) | 0 | 0.1 | 1 | 50 |
| Liver | ||||
| Hepatocellular adenoma | 1 | 2 | 1 | 1 |
| Hepatocellular carcinoma | 1 | 0 | 0 | 2 |
| Pancreas | ||||
| Acinar cell adenoma | 0 | 1 | 0 | 3 |
| Acinar cell carcinoma | 0 | 0 | 0 | 2 |
| Combined adenoma/carcinoma | 0 | 1 | 0 | 5* |
| Testes | ||||
| Leydig cell tumor | 4 | 4 | 1 | 8 |
| Females | ||||
| Dose level (mg/kg) | 0 | 1 | 50 | 500 |
| Liver | ||||
| Hepatocellular adenoma | 0 | 0 | 0 | 11* |
| Hepatocellular carcinoma | 0 | 0 | 0 | 4* |
| Pancreas | ||||
| Acinar cell adenoma | 0 | 0 | 0 | 0 |
| Acinar cell carcinoma | 0 | 0 | 0 | 0 |
| Combined adenoma/carcinoma | 0 | 0 | 0 | 0 |
*
Significantly different from control (p < 0.05).