Table 2.
Pooled data on Induction of CAs by NaF or γ-rays alone or in combination in HPBLs from 3 donors.
| Experimental condition | TM | Percentage ± SEM |
TM for cell cycle | Fixation hour | ||||
|---|---|---|---|---|---|---|---|---|
| Aberrant M | Chromatid break | Deletion | D + R | M1 cells | ||||
| Untreated | 348 | 3 ± 0.5 | 3 | 0 | 0 | 82 ± 2.5 | 444 | 56 |
| F-5 mM | 391 | 9 ± 0.5 | 7 | 2 ± 0.5 | 0 | 94 ± 1.0$ | 448 | |
| 1 Gy | 330 | 33 ± 3.5 | 4 | 12 ± 2.2 | 17 ± 1.4 | 89 ± 3.8$ | 428 | |
| F-5 mM +1 Gy | 327 | 47 ± 3.0* | 7 | 14 ± 1.7 | 31 ± 2.7# | 96 ± 1.0 | 421 | |
| 2 Gy | 337 | 47 ± 3.3 | 4 | 24 ± 3.5 | 26 ± 1.5 | 93 ± 2.9$ | 437 | |
| F-5 mM +2 Gy | 341 | 58 ± 3.7* | 7 | 32 ± 1.8 | 39 ± 1.4# | 97 ± 1.2 | 421 | |
| 4 Gy | 324 | 80 ± 1.2 | 2 | 42 ± 2.2 | 70 ± 6.3 | 97 ± 2.1$ | 410 | |
| F-5 mM +4 Gy | 323 | 90 ± 1.5* | 6 | 45 ± 4.4 | 87 ± 4.4# | 100 ± 0 | 386 | |
| Untreated | 326 | 2 ± 0.5 | 3 | 0 | 0 | 58 ± 4.6 | 458 | 72 |
| F-5 mM | 327 | 7 ± 1.4 | 6 | 1 ± 0.5 | 0 | 86 ± 2.6$ | 432 | |
| 1 Gy | 367 | 28 ± 4.9 | 2 | 13 ± 1.3 | 12 ± 2.6 | 74 ± 5.2$ | 420 | |
| F-5 mM +1 Gy | 330 | 40 ± 5.1* | 6 | 22 ± 3.6 | 21 ± 4.6# | 93 ± 3.1 | 391 | |
| 2 Gy | 330 | 41 ± 3.4 | 2 | 30 ± 4.9 | 23 ± 1.0 | 82 ± 3.2$ | 420 | |
| F-5 mM +2 Gy | 336 | 52 ± 1.8* | 7 | 41 ± 7.3 | 36 ± 1.0# | 96 ± 2.0 | 377 | |
| 4 Gy | 308 | 78 ± 0.9 | 0 | 49 ± 3.2 | 64 ± 6.1 | 89 ± 4.0$ | 392 | |
| F-5 mM +4 Gy | 321 | 89 ± 0.3* | 5 | 49 ± 2.5 | 76 ± 4.6# | 100 ± 0 | 361 | |
TM, total metaphase; M1, first cycle metaphases; D, dicentric; R, ring.
*
p < 0.001; significant using Fischer's exact test between radiation and F + radiation.
$
p < 0.001; significant using Fischer's exact test between untreated control and treatment either with F or radiation.
#
p < 0.001; significant using Freeman-Halton extension of the Fisher exact probability test for a two-rows by three-columns contingency table between radiation and F + radiation data.