Table 2.
Naringenin modulated the serum biochemical parameters in rats altered due to induced diabetes.
| SGOT (U/L) | SGPT (U/L) | ALP (U/L) | Creatinine (mg/dl) | Total glucose (mg/dl) | Cholesterol (mg/d l) | |
|---|---|---|---|---|---|---|
| Ctrl | 85.9 ± 5.8 | 234.7 ± 9.4 | 66.5 ± 7.9 | 0.5 ± 0.01 | 76.7 ± 4.9 | 122.4 ± 11.2 |
| Diab | 269.3 ± 7.3# | 599.4 ± 15.6# | 381.3 ± 11.0# | 1.2 ± 0.05# | 494.8 ± 7.5# | 255.9 ± 13.4# |
| CoN | 114.8 ± 8.5*** | 245.8 ± 11.1*** | 64.5 ± 3.9*** | 0.5 ± 0.02*** | 94.8 ± 5.2*** | 119.7 ± 8.8*** |
| PoN | 127.9 ± 5.8*** | 270.9 ± 12.8*** | 74.32 ± 5.4*** | 0.5 ± 0.03*** | 128.8 ± 6.4*** | 118.9 ± 0.7*** |
| Glib | 150.3 ± 8.4** | 289.5 ± 14.6*** | 130.9 ± 8.6** | 0.6 ± 0.05** | 203.8 ± 16.5* | 122.2 ± 1.2** |
| Sil | 132.4 ± 10.7** | 254.8 ± 11.1** | 102.5 ± 4.4*** | 0.4 ± 0.01** | 144.5 ± 10.3** | 132.6 ± 8.6** |
| CtN | 75.6 ± 5.9 | 241.9 ± 19.6 | 61.7 ± 8.3 | 0.4 ± 0.02 | 77.2 ± 8.1 | 91.2 ± 2.8 |
Each value represents the mean ± SE of six rats. Ctrl: Control rats; Diab: Diabetic rats; CoN: Diabetic rats co-treated with naringenin during streptozotocin induction; PoN: Diabetic rats treated with naringenin after diabetes induction; Glib: Diabetic rats treated with standard drug glybenclamide; Sil: Diabetic rats treated with Silymarin; CtN: Control rats treated with naringenin. # Denotes significant difference compared with control rats; *P < 0.05; **P < 0.01; ***P < 0.001 denotes significant difference compared with diabetic control.