Table 1.
Mean ± SD value of the toxicokinetic parameters of zearalenone (ZEA) following a single intravenous or oral administration at a dosage of 1.2 mg/kg bw in broiler chickens (n = 5).
| Toxicokinetic parameters (unit) | Value |
|---|---|
| Intravenous administration | |
| Kel (h) | 0.53 ± 0.11 |
| K12 (h−1) | 1.33 ± 0.10 |
| K21 (h−1) | 0.68 ± 0.17 |
| t1/2α (h) | 0.10 ± 0.01 |
| t1/2β (h) | 1.36 ± 0.29 |
| CL (L/h/kg) | 0.34 ± 0.03 |
| Vd (L/kg) | 6.40 ± 0.89 |
| MRT (h) | 2.1 ± 0.41 |
| Oral administration | |
| Cmax (ng/ml) | 15.9 ± 4.5 |
| Tmax (min) | 15.0 ± 0.0 |
| Fpo (%) | 29.66 ± 5.6 |
Kel, elimination rate constant; K12, K21, micro-rate constants; t1/2α, distribution half-life; t1/2β, elimination half-life; CL, clearance; Vd, volume of distribution; MRT, mean residence time; Cmax, maximum concentration; Tmax, time at maximum concentration; Fpo, oral bioavailability.