Table 1.

Mean ± SD value of the toxicokinetic parameters of zearalenone (ZEA) following a single intravenous or oral administration at a dosage of 1.2 mg/kg bw in broiler chickens (n = 5).

Toxicokinetic parameters (unit)	Value
Intravenous administration
Kel (h)	0.53 ± 0.11
K12 (h−1)	1.33 ± 0.10
K21 (h−1)	0.68 ± 0.17
t1/2α (h)	0.10 ± 0.01
t1/2β (h)	1.36 ± 0.29
CL (L/h/kg)	0.34 ± 0.03
Vd (L/kg)	6.40 ± 0.89
MRT (h)	2.1 ± 0.41
Oral administration
Cmax (ng/ml)	15.9 ± 4.5
Tmax (min)	15.0 ± 0.0
Fpo (%)	29.66 ± 5.6

K_el, elimination rate constant; K₁₂, K₂₁, micro-rate constants; t_1/2α, distribution half-life; t_1/2β, elimination half-life; CL, clearance; V_d, volume of distribution; MRT, mean residence time; C_max, maximum concentration; T_max, time at maximum concentration; F_po, oral bioavailability.