Table 3.
Effect of ADW on antioxidant enzymes catalase, glutathione peroxidase and superoxide dismutase activity during BPA induced toxicity in HepG2 cells. Values are Mean ± SEM of three independent experiments carried out in triplicates.
Groups | Catalasea | Glutathione peroxidiseb | Superoxide dismutasec |
---|---|---|---|
Control | 1.45 ± 0.18* | 28.68 ± 1.35* | 45.58 ± 1.56* |
Antimycin A (10 μM) | 0.58 ± 0.05** | 11.57 ± 0.98** | 20.97 ± 1.51** |
BPA (100 nM) | 0.48 ± 0.10** | 16.58 ± 1.68** | 28.28 ± 1.98** |
BPA (100 nM) + vitamin E (25 μM) | 0.84 ± 0.12* | 23.68 ± 1.32* | 35.64 ± 3.11* |
BPA (100 nM) + ADW (100 μg/ml) | 0.96 ± 0.09* | 20.67 ± 1.12* | 29.15 ± 2.61 |
Statistically significant at P < 0.05 compared to control.
Statistically significant at P < 0.05 compared to BPA.
μmol of H2O2 decomposed/min/mg protein.
μmol of NADPH oxidized/min/mg protein.
Units/mg protein.