Table 1.
Grade | Histological characteristics |
---|---|
1-Mild | Steatosis: predominantly macrovesicular |
Ballooning: occasionally observed | |
Lobular inflammation: scattered and mild acute inflammation | |
2-Moderate | Steatosis: any degree usually mixed macrovesicular and microvesicula |
Ballooning: obvious and present in centrilobular zone | |
Lobular inflammation: associated with ballooned hepatocytes | |
3-Severe | Steatosis: typically involves >66% of lobules |
Ballooning: predominantly, marked in centrilobular zone | |
Lobular inflammation: scattered acute and chronic inflammation |
According to Brunt et al. grading and staging system for NASH [7].