Table 3.
Effect of 4-NP on liver oxidative stress and antioxidant enzyme activity in all experimental groups. Doses of 4-NP (mg/kg b.wt.).
| CAT (U/mg prot) | GSH-Px (U/mg prot) | SOD (U/mg prot) | H2O2 (μmol/mg prot) | MDA (nmol/mg prot) | |
|---|---|---|---|---|---|
| Control | 14.045 ± 2.08 | 1.932 ± 0.15 | 14.502 ± 2.79 | 2.045 ± 0.41 | 1.461 ± 0.49 |
| 2 mg | 10.23 ± 1.91** | 1.280 ± 0.45** | 14.156 ± 2.18 | 2.428 ± 1.00 | 1.881 ± 0.55 |
| 10 mg | 5.833 ± 2.67*** | 0.632 ± 0.39*** | 12.359 ± 1.82 | 2.451 ± 0.28 | 3.013 ± 0.46** |
| 50 mg | 4.318 ± 2.28*** | 0.471 ± 0.29*** | 10.414 ± 2.20* | 3.066 ± 0.47** | 3.199 ± 0.81** |
Effect of 4-NP on liver antioxidant enzymes and reactive oxygen species. Values are expressed as mean ± SD, n = 6. The symbol represents statistical significant (ANOVA) from control.
*
p < 0.05.
**
p < 0.01.
***
p < 0.001.