REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Anti-RIP3 (phospho S227) antibody	Abcam	Cat# ab209384
Anti-c-Jun Rabbit polyclonal Antibody	Abcam	Cat# ab31367; RRID: AB_731606
Purified Mouse Anti-RIP Antibody (38/RIP) (Immunofluorescent imaging)	BD Biosciences	Cat# 610459; RRID: AB_397832
Phospho Histone H2A.X (ser139) (20E3) Rabbit mAb	Cell Signaling Technologies	Cat# 9718; RRID: AB_2118009
RIP (D94C12) XP Rabbit Mab	Cell Signaling Technology	Cat# 3493; RRID: AB_2305314
Anti-Caspase-3 antibody	Cell Signaling Technology	Cat# 9662; RRID: AB_331439
Phospho-p53 (Ser15) (D4S1H) Rabbit mAb	Cell Signaling Technology	Cat# 12571
GAPDH (D16H11) XP Rabbit mAb	Cell Signaling Technology	Cat# 5174; RRID: AB_10622025
PCNA (PC10) Mouse mAb	Cell Signaling Technology	Cat# 2586; RRID: AB_2160343
Phospho-ATM (Ser1981) (D6H9) Rabbit mAb	Cell Signaling Technology	Cat# 5883; RRID: AB_10835213
Phospho-Chk1 (Ser345) (133D3) Rabbit mAb	Cell Signaling Technology	Cat# 2348; RRID: AB_331212
Phospho-SAPK/JNK (Thr183/Tyr185) Antibody	Cell Signaling Technology	Cat# 9251; RRID: AB_331659
Phospho-Chk2 (Thr68) Antibody	Cell Signaling Technology	Cat# 2661; RRID: AB_331479
Phospho-ATR (Ser428) Antibody	Cell Signaling Technology	Cat# 2853; RRID: AB_2290281
Phospho-BRCA1 (Ser1524) Antibody	Cell Signaling Technology	Cat# 9009; RRID: AB_491003
Cleaved Caspase-3 (Asp175) (5A1E) Rabbit mAb	Cell Signaling Technology	Cat# 9664; RRID: AB_2070042
Cleaved Caspase-8 (Asp387) (D5B2) XP Rabbit mAb	Cell Signaling Technology	Cat# 8592
RIP (D94C12) XP Rabbit mAb	Cell Signaling Technology	Cat# 3493; RRID: AB_2305314
Cleaved Caspase-1 (Asp296) Antibody	Cell Signaling Technology	Cat# 67314
Phospho-p38 MAPK (Thr180/Tyr182) (D3F9) XP Rabbit mAb	Cell Signaling Technology	Cat# 4511; RRID: AB_2139682
p38 MAPK (D13E1) XP Rabbit mAb	Cell Signaling Technology	Cat# 8690; RRID: AB_10999090
c-IAP1 Rabbit polyclonal Antibody	Cell Signaling Technology	Cat# 4952; RRID: AB_2063660
c-IAP2 (58C7) Rabbit mAb	Cell Signaling Technology	Cat# 3130; RRID: AB_10693298
XIAP Rabbit polyclonal Antibody	Cell Signaling Technology	Cat# 2042; RRID: AB_2214870
PARP Rabbit polyclonal Antibody	Cell Signaling Technology	Cat# 9542; RRID: AB_2160739
Caspase-8 Rabbit polyclonal Antibody	Cell Signaling Technology	Cat# 4927; RRID: AB_2068301
Alexa Fluor 488 Goat anti-Rat IgG (Immunofluorescent imaging)	Life Technologies	Cat# A11006; RRID: AB_141373
Alexa Fluor 546 Goat anti-Rabbit (Immunofluorescent imaging)	Life Technologies	Cat# A11010; RRID: AB_143156
Goat anti-Mouse IgG Alexa Fluor 488 (Immunofluorescent imaging)	Life Technologies	Cat# A11029; RRID: AB_138404
NA19L Anti-replication Protein A (Ab-3) Mouse mAb (RPA34-20)	Merck (Calbiochem)	Cat# NA19L; RRID: AB_565123
Ki-67 (SP6) Rabbit mAb	Neomarkers / Lab vision Corporation	Cat# RM9106; RRID: AB_2335745
Cleaved caspase-8 Rabbit polyclonal Antibody	Novus Biologicals	Cat# NB100-56116; RRID: AB_837874
Chk1 [p Ser317] Rabbit polyclonal Antibody	Novus Biologicals	Cat# NB100-92499; RRID: AB_1216466
p-Chk2 [p Thr68] Rabbit polyclonal Antibody	Novus Biologicals	Cat# NB100-92502; RRID: AB_1216474
gamma H2AX [p Ser139] Rabbit polyclonal Antibody (Immunofluorescent imaging)	Novus Biologicals	Cat# NB100-2280; RRID: AB_10000580
gamma H2AX (p Ser139) Rabbit polyclonal Antibody	Novus Biologicals	Cat# NB100-384; RRID: AB_350295
SHARPIN Rabbit polyclonal Antibody	Proteintech	Cat# 14626-1-AP; RRID: AB_2187734
Caspase-8 p18 Antibody (H-134)	Santa Cruz Biotechnology	Cat# sc-7890; RRID: AB_2068330
p-c-Jun Goat polyclonal Antibody (Ser 63/73)	Santa Cruz Biotechnology	Cat# sc-16312; RRID: AB_2129883
p-Akt1/2/3 Rabbit polyclonal Antibody (Ser 473)	Santa Cruz Biotechnology	Cat# sc-7985-R; RRID: AB_667741
Akt1/2 Goat polyclonal Antibody (N-19)	Santa Cruz Biotechnology	Cat# sc-1619; RRID: AB_671713
53BP1 Rabbit polyclonal Antibody (H-300) (Immunofluorescent imaging)	Santa Cruz Biotechnology	Cat# sc-22760; RRID: AB_2256326
Human HOIP/RNF31 Antibody	R&D Systems	Cat# AF8039
Anti-BrdU antibody, Mouse Monoclonal (clone BU-33)	Sigma-Aldrich	Cat# B8434; RRID: AB_476811
Anti-actin N terminal antibody	Sigma Aldrich	Cat# A2103; RRID: AB_476694
Anti-ATM Mouse mAb	Sigma-Aldrich	Cat# A1106; RRID: AB_796190
C15 (anti-caspase 8)	Prof. Peter H Krammer (DKFZ, Heidelberg)	N/A
1C4 (anti-FADD)	Prof. Peter H Krammer (DKFZ, Heidelberg)	N/A
Human HOIL-1 Antibody	Prepared in house	Haas et al., 2009
Bacterial and Virus Strains
lentiviral particles for caspase-8	Santa Cruz	Cat# sc-29930-V
lentiviral particles for control	Santa Cruz	Cat# sc-108080
Biological Samples
Liver tissue from mice after Vitamin E diet	This paper	N/A
Liver tissue from mice after BHA diet	This paper	N/A
Liver tissue from mice after two-third partial hepatectomy	Speicher et al., 2014	N/A
Liver Tissue from mice after LPS/D-Gal treatment	This paper	N/A
Liver tissue from mice after Doxorubicin treatment	This paper	N/A
Liver tissue from various mutant mice and intercrossings	Vick et al., 2009, Vucur et al., 2013, Olayioye et al., 2005, Kang et al., 2008, Das et al., 2011, Dillon et al., 2014, this paper	N/A
Chemicals, Peptides, and Recombinant Proteins
Doxorubicin	Sigma-Aldrich	Cat# D1515
DMSO	Sigma-Aldrich	Cat# 276855
Q-VD-OPH	Sigma-Aldrich	Cat# SML0063
Necrostatin1	Sigma-Aldrich	Cat# N9037
D-(+)-Galactosamine	Sigma-Aldrich	Cat# G0500
Lipopolysaccharide	Sigma-Aldrich	Cat# F3665
Buprenorphine	MSD Sharp & Dohme GmbH	NDC 12496-0757-5
DAPI	Life Technologies	Cat# D1306
Puromycin (CAS 53-79-2)	Santa Cruz	Cat# sc-205821
Caspase 8 inhibitor (Z-IETD-FMK)	Selleckchem	Cat# S7314
ATM kinase inhibitor Ku-55933	Selleckchem	Cat# S1092
JNK inhibitor SP600125	Selleckchem	Cat# S1460
Caspase 1 inhibitor (YVAD-CMK)	Merck (Calbiochem)	Cat# 400012
Critical Commercial Assays
LIVE/DEAD Fixable Dead Cell Stain Kit	Invitrogen	Cat# L23102
RNeasy Mini Kit	Qiagen	Cat# 74106
Quantitect Reverse Transcription Kit	Qiagen	Cat# 205313
Fast Start SYBR Green Master Rox	Roche	Cat# 04913850001
TaqMan™ Copy Number Assays	Thermo Fisher	Cat# 4400291
Human Wwox	Thermo Fisher	Cat# 4400291
Human Spata22	Thermo Fisher	Cat# 4400291
Human Fhit	Thermo Fisher	Cat# 4400291
Human Fgfr1	Thermo Fisher	Cat# 4400291
Human Fgr	Thermo Fisher	Cat# 4400291
Murine Wwox	Thermo Fisher	Cat# 4400291
Murine Spata22	Thermo Fisher	Cat# 4400291
Murine Fhit	Thermo Fisher	Cat# 4400291
Murine Fgfr1	Thermo Fisher	Cat# 4400291
Murine Fgr	Thermo Fisher	Cat# 4400291
Mouse DNA Microarray 4x 44K	Agilent	Cat# G4122F
Deposited Data
Mouse RNA expression data	This paper	The accession number for the data reported in this paper is: GSE75730
Datasets for Gene Set Enrichment Analysis (GSEA)	Molecular Signatures Database	http://www.broadinstitute.org
Clinical and RNA sequencing data from human HCC	The Cancer Genome Atlas (TCGA)	https://tcga-data.nci.nih.gov/
Methylation data from human HCC	TCGA, via cBioPortal	http://www.cbioportal.org/
Experimental Models: Cell Lines
U2OS	Massimo Lopes	N/A
p19-/- MEFs	Emmanuel Dejardin	N/A
Experimental Models: Organisms/Strains
JNK1/2flox/flox	Roger J. Davis	N/A
Mcl-1flox/flox	Joseph T. Opferman	N/A
Tak1Δhep	Tom Luedde	N/A
Casp8Δhep	Tom Luedde	N/A
Tak1/Casp8Δhep	Tom Luedde	N/A
Tak1Δhep/RIPK3-/-	Tom Luedde	N/A
Xiap−/−	Philip Jost	N/A
caspase 8 D387	David Wallach	N/A
cFLIPΔhep	Jörn M Schattenberg
TNFR1-/-	Mathias Heikenwälder	N/A
TNFR1/2-/-	Jackson	JAX: 003243
Ripk1-/-/Ripk3−/−/Casp8−/−	Douglas Green	N/A
Ripk1-/-/Ripk3−/−FADD−/−	Douglas Green	N/A
Ripk3−/−/Casp8−/−	Douglas Green	N/A
Ripk3−/−	Douglas Green/ Tom Luedde	N/A
RIPK1KD	Douglas Green	N/A
Oligonucleotides
Murine Mcl-1 Fwd TCAAAGATGGCGTAACAAACTGG Rev CCCGTTTCGTCCTTACAAGAAC	This paper	N/A
Murine Tnf-α Fwd CATCTTCTCAAAATTCGAGTGACAA Rev TGG GAGTAGACAAGGTACAACCC	This paper	N/A
Murine Trail Fwd CGGGCAGATCACTACACCC Rev TGTTACTGGAACAAAGACAGCC	This paper	N/A
Murine TrailR Fwd AGTAGTGCTGCTGATTGGAG Rev CCTGTTTTCTGAGTCTTGCC	This paper	N/A
Murine Fas Fwd TGCACCCTGACCCAGAATAC Rev GCCAGGAGAATCGCAGTAGAA	This paper	N/A
Murine FasL Fwd GCAAATAGCCAACCCCAGTACAC Rev GCCACCTTTCTTATACTTCACTCCAG	This paper	N/A
Murine Tnfr1 Fwd CACCGTGACAATCCCCTGTAA Rev TTTGCAAGCGGAGGAGGTAG	This paper	N/A
Murine Tnfr2 Fwd ACAAAGTACCAAGGGTGGCA Rev GGGCTTCTTTTTCCTCTGCAC	This paper	N/A
Murine IL-6 Fwd TAGTCCTTCCTACCCCAATTTCC Rev TTGGTCCTTAGCCACTCCTTC	This paper	N/A
Murine IL-1α Fwd CGA AGC TCT CCG TAC ATT CC Rev TAA GGA CGG GAG GGA GAA AG	This paper	N/A
Murine IL-1β Fwd TAA GGA CGG GAG GGA GAA AG Rev GAT CCA CAC TCT CCA GCT GCA	This paper	N/A
Murine IL-18 Fwd GAC TCT TGC GTC AAC TTC AAG G Rev CAG GCT GTC TTT TGT CAA CGA	This paper	N/A
Murine Ifn-γ Fwd GCA TCC AAA AGA GTG TGG AG Rev GCA GGC AGG ACA ACC ATT AC	This paper	N/A
Murine Gadd45a Fwd AGC ACG CAA AAG GTC ACA TTG Rev GGG AAA GCA CTG CAC GAA CT	This paper	N/A
Murine Actin Fwd GTGGGCCGCCCTAGGCACCA Rev CTCTTTGATGTCACGCACGATTTC	This paper	N/A
Murine GAPDH Fwd CCACCCCAGCAAGGAGACT Rev GAAATTGTGAGGGAGATGCT	This paper	N/A
Murine Rad51 Fwd CGGGAGTTGGTGGGTTATCC Rev CCGGCACATCTTGGTTTATTTGT	This paper	N/A
Murine Exo1 Fwd ATGGGGATTCAAGGGTTACTTCA Rev AGCCAACAGTAGGTATCCACAG	This paper	N/A
Murine Ddit3 Fwd CTCGCTCTCCAGATTCCAGTC Rev CTTCATGCGTTGCTTCCCA	This paper	N/A
Murine PolE2 Fwd TCCTCGAACATGATCGAACGA Rev ACGTGGAATATCAAAAGCTCCAA	This paper	N/A
Murine PolQ Fwd GCTTGGTCACGTCTTGGAAG Rev GGGCAAAATAAACAACGCTTTCT	This paper	N/A
Murine Ddb1 Fwd ATGTCGTACAACTACGTCGTAAC Rev CTGAAGTAAAGTGTCCGGTCAC	This paper	N/A
Murine Chek2 Fwd CTGAAGTAAAGTGTCCGGTCAC Rev CACCACCCGGTCAAATAGTTC	This paper	N/A
Murine Lig1 Fwd CCAGCTCATAGTCCCCTCTGA Rev GTCTTGGCACCTCTAGCAGG	This paper	N/A
Human Actin Fwd ATGGCCCTGTGCCTTAGTAG Rev GGTCTCAAACATGATCTGGG	This paper	N/A
Human GAPDH Fwd CCT GGT CAC CAG GGC TGC Rev CCG TTC TCA GCC TTG ACG G	This paper	N/A
Human Rad51 Fwd TTTGGTGAGTTTCCCGCTGTC Rev AACTTCTTTGCTAAGCTCGGAG	This paper	N/A
Human Exo1 Fwd CCTCGTGGCTCCCTATGAAG Rev AGGAGATCCGAGTCCTCTGTAA	This paper	N/A
Human Ddit3 Fwd GGAAACAGAGTGGTCATTCCC Rev CTGCTTGAGCCGTTCATTCTC	This paper	N/A
Human PolE2 Fwd TGAGAAGCAACCCTTGTCATC Rev TCATCAACAGACTGACTGCATTC	This paper	N/A
Human PolQ Fwd ACCTCTCCATCAAGGCATTTCT Rev GCAAAAGTTCCAGCAGATACC	This paper	N/A
Human Ddb1 Fwd ACCGGACACTTTACTTCGGC Rev TCGGCGGTGACCACATAGA	This paper	N/A
Human Chek2 Fwd TGAGAACCTTATGTGGAACCCC Rev ACAGCACGGTTATACCCAGC	This paper	N/A
Human Lig1 Fwd ACAGTTCCCCATCAGGGATTC Rev CTCTGTGAGGCTTTCTTTCGG	This paper	N/A
Human Gpnmb Fwd AAGTGAAAGATGTGTACGTGGTAACAG Rev TCGGATGAATTTCGATCGTTCT	This paper	N/A
Human Tinag Fwd CGAAAGCTTCAGACACATGC Rev TTTCTTTCTGCCCTTGTGCT	This paper	N/A
Human Plk1 Fwd GCTTAATGACGAGTTCTTTACTTC Rev TCGAAAACCTTGGTGGAATG	This paper	N/A
Human Bcl2a1b Fwd ACGACAGCAAATTGCCCCGGAT Rev AAGCCATTTTCCCAGCCTCCGT	This paper	N/A
Human Tpx2 Fwd CGAAAGCATCCTTCATCTCC Rev TCCTTGGGACAGGTTGAAAG	This paper	N/A
Human CD44 Fwd CCGCTATGTCCAGAAAGGA Rev CTGTCTGTGCTGTCGGTGAT	This paper	N/A
Human Glypican3 Fwd CCTTTGAAATTGTTGTTCGCCA Rev CCTGGGTTCATTAGCTGGGTA	This paper	N/A
Human Epcam Fwd AATCGTCAATGCCAGTGTAC Rev TCTCATCGCAGTCAGGATCATAA	This paper	N/A
Human Afp Fwd AACTATTGGCCTGTGGCGAG Rev TCATCCACCACCAAGCTG	This paper	N/A
D3S1263-Fwd (FAM labeled) CTG TTG ACC CAT TGA TAC CC	Thermo Fisher	N/A
D3S1263-Rev (HEX labeled) TAA AAT CAC AGC AGG GGT TC	Thermo Fisher	N/A
D3S1289-Fwd (HEX labeled) AAA GCA ACT TGT AAG AGA GCA	Thermo Fisher	N/A
D3S1289-Rev (FAM labeled) CTC CTA GAT ATA ATC ACT GGC A	Thermo Fisher	N/A
Software and Algorithms
Copy Caller Software	Life Technologies	https://www.thermofisher.com
FlowJo sofware	TreeStar	https://www.flowjo.com
Summit software v4.3	Beckman Coulter	https://www.beckman.com
GeneMapper software	Applied Biosystems	https://www.thermofisher.com
NDP Viewer v1.2.36	NDP View	https://www.hamamatsu.com
Tissue IA image 2.0	Leica Biosystems	www.leicabiosystems.com
GeneSpring GX	Agilent	http://www.genomics.agilent.com
GESA Molecular Signatures Database		http://www.broadinstitute.org
Xcalibur software 2.2	Thermo Fisher Scientific	https://www.thermofisher.com
R statistical programming language 3.2.2	R Foundation for Statistical Computing	https://www.R-project.org/
cgdsr R package (R-Based API for Accessing the MSKCC Cancer Genomics Data Server (CGDS))	CRAN repository	https://CRAN.R-project.org/package=cgdsr
SCAN.UPC R package	Bioconductor project	https://bioconductor.org/packages/SCAN.UPC
Other
ABI 3130XL Genetic Analyzer	Applied Biosystems	https://www.thermofisher.com
Stella 3200 imaging system	Raytest	https://www.raytest.com/
Nano Zoomer C9600 Virtual Slide Light microscope scanner	Hamamatsu	https://www.hamamatsu.com