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. 2017 Sep 8;10:4379–4391. doi: 10.2147/OTT.S143518

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© 2017 Hu et al. This work is published and licensed by Dove Medical Press Limited

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DEPTOR knockdown induced cell cycle arrest and apoptosis in osteosarcoma cells.

Notes: (A) Flow cytometric analysis of the percentage of cells transfected with NC siRNA or DEPTOR siRNA in various phases of the cell cycle. (B) Flow cytometric analysis of the percentage of cells in different phases of the cell cycle with three independent experiments. (C) Flow cytometric analysis of apoptotic cells by Annexin V-FITC/PI staining; in all four plots, the right upper and right lower quadrants show apoptotic cells. (D) The proportion of apoptotic cells in MG63 and MNNG/HOS cells. Data are expressed as mean ± SD of three independent experiments (**P<0.01, ***P<0.001 compared with nonspecific siRNA group).

Abbreviations: DEPTOR, DEP-domain containing mTOR-interacting protein; FITC, fluorescein isothiocyanate; NC siRNA, nonspecific siRNA; PI, propidium iodide.